发明申请
US20110136845A1 (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof
有权
（+） - 吗啡喃作为Toll样受体9的拮抗剂及其治疗用途
- 专利标题： (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof
- 专利标题（中）： （+） - 吗啡喃作为Toll样受体9的拮抗剂及其治疗用途
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申请号： US12975407申请日： 2010-12-22
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公开(公告)号： US20110136845A1公开(公告)日： 2011-06-09
- 发明人: Bobby N. Trawick , David W. Berberich , Christopher W. Grote
- 申请人： Bobby N. Trawick , David W. Berberich , Christopher W. Grote
- 申请人地址： US MO Hazelwood
- 专利权人： Mallinckrodt Inc.
- 当前专利权人： Mallinckrodt Inc.
- 当前专利权人地址： US MO Hazelwood
- 主分类号： A61K31/485
- IPC分类号： A61K31/485 ; C07D489/08 ; C07D217/20 ; A61K31/472 ; C07D489/02 ; C07D489/00 ; A61P29/00 ; A61P25/04
摘要：
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
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