发明申请
- 专利标题： AMPHIPHILIC BLOCK COPOLYMERS FOR NUCLEIC ACID DELIVERY
- 专利标题（中）： 用于核酸递送的嵌段共聚物
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申请号： US12991321申请日： 2009-05-14
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公开(公告)号： US20110151013A1公开(公告)日： 2011-06-23
- 发明人: Andrew Lennard Lewis , Giuseppe Battaglia , Irene Canton , Peter William Stratford
- 申请人： Andrew Lennard Lewis , Giuseppe Battaglia , Irene Canton , Peter William Stratford
- 申请人地址： GB Farnham, Surrey
- 专利权人： BIOCOMPATIBLES UK LIMITED
- 当前专利权人： BIOCOMPATIBLES UK LIMITED
- 当前专利权人地址： GB Farnham, Surrey
- 优先权： EP08156272.0 20080515
- 国际申请： PCT/EP2009/055864 WO 20090514
- 主分类号： A61K9/51
- IPC分类号： A61K9/51 ; A61K9/00 ; C12N5/071 ; A61K31/7105 ; B82Y5/00
摘要：
The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
公开/授权文献
- US09254258B2 Amphiphilic block copolymers for nucleic acid delivery 公开/授权日：2016-02-09
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