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公开(公告)号:US09254258B2
公开(公告)日:2016-02-09
申请号:US12991321
申请日:2009-05-14
IPC分类号: A61K9/51 , A61K9/00 , C12N5/071 , A61K31/7105 , B82Y5/00 , A61K9/127 , A61K48/00 , C12N15/11
CPC分类号: A61K9/1273 , A61K9/0019 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要: The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
摘要翻译: 本发明提供包含囊泡并包封在囊泡内的组合物,其包含小于1000个核苷酸的核酸,其中囊泡包含具有亲水和疏水嵌段的两亲性嵌段共聚物。 还提供了形成囊泡的方法和将核酸,特别是将iRNA递送到细胞中的方法。
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公开(公告)号:US20110151013A1
公开(公告)日:2011-06-23
申请号:US12991321
申请日:2009-05-14
IPC分类号: A61K9/51 , A61K9/00 , C12N5/071 , A61K31/7105 , B82Y5/00
CPC分类号: A61K9/1273 , A61K9/0019 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要: The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
摘要翻译: 本发明提供包含囊泡并包封在囊泡内的组合物,其包含小于1000个核苷酸的核酸,其中囊泡包含具有亲水和疏水嵌段的两亲嵌段共聚物。 还提供了形成囊泡的方法和将核酸,特别是将iRNA递送到细胞中的方法。
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