利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

129 条记录 (耗时 0.053 秒)

    CRYOABLATION SYSTEM WITH MAGNETIC RESONANCE IMAGING DETECTION
    1.
    发明申请
    CRYOABLATION SYSTEM WITH MAGNETIC RESONANCE IMAGING DETECTION 有权

    公开(公告)号：US20220369931A1

    公开(公告)日：2022-11-24

    申请号：US17882065

    申请日：2022-08-05

    申请人： Biocompatibles UK Limited

    发明人： Daniel T. Kollmann ,  Timothy J, Davis ,  Satish Ramadhyani ,  Luan T. Chan

    IPC分类号： A61B5/00 ,  A61B18/02 ,  A61B5/055 ,  G01K3/00

    摘要： A magnetic resonance imaging (MRI) guided surgical system is provided that includes one or more surgical tools having components configured to develop reactive effects when exposed to MR signals generated by the MRI system. The system includes a control system that can determine whether the MR system is generating MR signals, and if the control system determines that the MR system is generating MR signals, mitigates the reactive effects of MR signals on components of the surgical tools. The system can include a cryoablation system with a cryoprobe having a probe shaft being made of a metallic material. If the control system determines that the MR system is generating MR signals, the control system can electrically disconnect the cryoprobe and/or ignore electrical signals generated by the electric heater in response to exposure to MR signals, and/or initiate a cooling operation of the probe shaft, whereby the cooling operation.

    Distributing Microparticles
    2.
    发明申请
    Distributing Microparticles 有权

    公开(公告)号：US20220331459A1

    公开(公告)日：2022-10-20

    申请号：US17736435

    申请日：2022-05-04

    申请人： Biocompatibles UK Limited ,  Oxford University Innovation Limited

    发明人： Jonathan James VINCE ,  Eleanor Phoebe Jane STRIDE

    IPC分类号： A61K51/12 ,  A61K41/00

    摘要： A method of distributing microparticles is provided, the method comprising: providing a plurality of microparticles at an insertion site in a medium; applying ultrasound to the insertion site that generates gas bubbles by cavitation at cavitation nuclei located at the insertion site and drives movement of the gas bubbles such that the gas bubbles drive movement of the microparticles into a desired spatial distribution in the tumour. The method may be a method of treating a tumour, and the microparticles may comprise a radioisotope for treating the tumour. Microparticles for use in the treatment of a tumour by the method are also disclosed.

    RADIOPAQUE POLYMERS
    3.
    发明申请
    RADIOPAQUE POLYMERS 有权

    公开(公告)号：US20210277162A1

    公开(公告)日：2021-09-09

    申请号：US17252560

    申请日：2019-12-26

    申请人： BIOCOMPATIBLES UK LIMITED

    发明人： Andrew Lennard LEWIS ,  Hugh BRITTON ,  Yiqing TANG ,  Jonathan VINCE ,  Koorosh ASHRAFI ,  Damien GUEGAN

    IPC分类号： C08F261/04 ,  A61K9/16 ,  A61K9/00 ,  C08G67/00 ,  A61L24/00 ,  A61K49/04 ,  A61L24/04

    摘要： A hydrophilic polymer comprising pendent groups of the formula I: Wherein: W is independently selected from —OH, —COOH, —SO3H, —OPO3H, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1—(C═O)—O—C1-4alkyl and —O—(C═O)C1-4alkyl; or a group —BZ; wherein —OH, COOH, O—PO3H and SO3H maybe in the form of a pharmaceutically acceptable salt; wherein: B is a bond, or a straight branched alkanediyl, oxyalkylene, alkylene oxaalkylene, or alkylene (oligooxalkylene) group, optionally containing one or more fluorine substituents; and Z is an ammonium, phosphonium, or sulphonium phosphate or phosphonate ester zwitterionic group; X is either a bond or a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; G is a coupling group through which the group of the formula I is coupled to the polymer and is selected from ether, ester, amide, carbonate, carbamate, 1,3 dioxolone, and 1,3 dioxane; R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2 q is an integer from to 4; n is an integer from 1 to 4; p is an integer from 1 to 3; and n+p is from 2 to 5; and wherein —COOH, —OPO3H2 and —SO3H as well as phenolic —OH maybe in the form of a pharmaceutically acceptable salt.

    METHOD OF MONITORING LIVE CELLS
    5.
    发明申请
    METHOD OF MONITORING LIVE CELLS 审中-公开

    公开(公告)号：US20160258962A1

    公开(公告)日：2016-09-08

    申请号：US15155308

    申请日：2016-05-16

    申请人： BIOCOMPATIBLES UK LIMITED

    发明人： Giuseppe BATTAGLIA

    IPC分类号： G01N33/58

    CPC分类号： G01N33/586 ,  G01N33/5005 ,  G01N33/582

    摘要： The present invention relates to a method of monitoring live cells, comprising the sequential steps of: (i) contacting the cells with self-assembled constructs associated with an imaging agent at t=0; (ii) incubating the cells for a period of time t1; (iii) imaging at least a sample of the live cells by means of the said imaging agent after time t1; wherein in step (i), at least some of the constructs are taken up into the cells; and wherein the constructs comprise an amphiphilic block copolymer having a hydrophilic and hydrophobic block.

    DERIVATISATION OF BIOLOGICAL MOLECULES
    9.
    发明申请
    DERIVATISATION OF BIOLOGICAL MOLECULES 有权
    生物分子的衍生物

    公开(公告)号：US20140030210A1

    公开(公告)日：2014-01-30

    申请号：US14037777

    申请日：2013-09-26

    申请人： BIOCOMPATIBLES UK LIMITED

    发明人： Stephen James BROCCHINI ,  Antony Robert GODWIN ,  Yiqing TANG ,  Andrew Lennard LEWIS

    IPC分类号： C07K17/08 ,  C08F30/02

    CPC分类号： A61K47/48176 ,  A61K38/00 ,  A61K38/21 ,  A61K47/58 ,  A61K47/60 ,  C07C323/22 ,  C07K17/08 ,  C08F4/00 ,  C08F4/06 ,  C08F30/02 ,  C08F130/02

    摘要： The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-α.

    摘要翻译： 本公开涉及一种新的聚合方法，其中烯属不饱和单体通过活性自由基聚合方法在引发剂和催化剂存在下聚合。 通过这种新方法生产的聚合物也被认为是新的，可用于衍生生物分子以提高其作为治疗疗法的功效。 优选的聚合物具有下式聚合物特别适用于衍生化蛋白质，例如干扰素-α。