发明申请
US20110151447A1 METHOD TO PRODUCE INDUCED PLURIPOTENT STEM (IPS) CELLS FROM NON-EMBRYONIC HUMAN CELLS
审中-公开
从非胚胎人类细胞中产生诱导性脑脊液干细胞（IPS）细胞的方法
- 专利标题： METHOD TO PRODUCE INDUCED PLURIPOTENT STEM (IPS) CELLS FROM NON-EMBRYONIC HUMAN CELLS
- 专利标题（中）： 从非胚胎人类细胞中产生诱导性脑脊液干细胞（IPS）细胞的方法
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申请号： US12741632申请日： 2008-11-06
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公开(公告)号： US20110151447A1公开(公告)日： 2011-06-23
- 发明人: In-Hyun Park , George Q. Daley , Suneet Agarwal , Paul Hubert Lerou
- 申请人： In-Hyun Park , George Q. Daley , Suneet Agarwal , Paul Hubert Lerou
- 申请人地址： US MA BOSTON
- 专利权人： CHILDREN'S MEDICAL CENTER CORPORATION
- 当前专利权人： CHILDREN'S MEDICAL CENTER CORPORATION
- 当前专利权人地址： US MA BOSTON
- 国际申请： PCT/US08/12532 WO 20081106
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; C12Q1/68 ; C12N15/85 ; C12N5/10
摘要：
The invention provides methods for generating induced pluripotent stem (iPS) cells from normal and mutant adult cells, as well as the iPS cells so generated from such methods. In some aspects, iPS cells are generated by ectopically expressing SOX2 and OCT4 nucleic acids in such adult cells. Other nucleic acids such as but not limited to MYC may also be ectopically expressed in such adult cells in the methods described herein.
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