发明申请
US20110229937A1 CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE
有权
CORYNEBACTERIUM GLUTAMICUM GENES编码参与甲磺酸生产的法规蛋白质
- 专利标题: CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE
- 专利标题(中): CORYNEBACTERIUM GLUTAMICUM GENES编码参与甲磺酸生产的法规蛋白质
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申请号: US13018119申请日: 2011-01-31
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公开(公告)号: US20110229937A1公开(公告)日: 2011-09-22
- 发明人: Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
- 申请人: Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
- 申请人地址: DE Essen
- 专利权人: Evonik Degussa GMBH
- 当前专利权人: Evonik Degussa GMBH
- 当前专利权人地址: DE Essen
- 优先权: DE19930476.9 19990701; DE19931419.5 19990708; DE19931420.9 19990708; DE19932122.1 19990709; DE19932128.0 19990709; DE19932134.5 19990709; DE19932206.6 19990709; DE19932207.4 19990709; DE19933003.4 19990714; DE19941390.8 19990831; DE19942088.2 19990903; DE19942124.2 19990903
- 主分类号: C12P19/40
- IPC分类号: C12P19/40 ; C12P13/12 ; C12N15/63 ; C12P13/04
摘要:
Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.
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