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    Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis
    1.
    发明授权
    Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis 有权
    使用具有降低甲硫氨酸生物合成负调节子的表达活性的微生物生产甲硫氨酸的方法

    公开(公告)号：US08389251B2

    公开(公告)日：2013-03-05

    申请号：US13018119

    申请日：2011-01-31

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    IPC分类号： C12P13/12 ,  C12N15/74

    CPC分类号： C07K14/34

    摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，称为MR核酸分子，其涉及精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种MR分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及在产生精细化学物质例如甲硫氨酸的条件下培养具有选择的MR基因缺失或突变的重组微生物。

    CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE
    2.
    发明申请
    CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE 有权
    CORYNEBACTERIUM GLUTAMICUM GENES编码参与甲磺酸生产的法规蛋白质

    公开(公告)号：US20110229937A1

    公开(公告)日：2011-09-22

    申请号：US13018119

    申请日：2011-01-31

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    IPC分类号： C12P19/40 ,  C12P13/12 ,  C12N15/63 ,  C12P13/04

    CPC分类号： C07K14/34

    摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，称为MR核酸分子，其涉及精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种MR分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及在产生精细化学物质例如甲硫氨酸的条件下培养具有选择的MR基因缺失或突变的重组微生物。

    Nucleic acid molecules encoding metabolic regulatory proteins from Corynebacterium glutamicum, useful for increasing the production of methionone by a microorganism
    3.
    发明授权
    Nucleic acid molecules encoding metabolic regulatory proteins from Corynebacterium glutamicum, useful for increasing the production of methionone by a microorganism 失效
    编码来自谷氨酸棒杆菌的代谢调节蛋白的核酸分子，用于增加微生物产生的甲硫氨酸

    公开(公告)号：US07892798B2

    公开(公告)日：2011-02-22

    申请号：US10307138

    申请日：2002-11-29

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    IPC分类号： C12P13/12 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C07K14/34

    摘要： Isolated nucleic acid molecules, which encode novel metabolic regulatory proteins from Corynebacterium glutamicum are described. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing metabolic regulatory nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one metabolic regulatory molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected metabolic regulatory genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型代谢调节蛋白的分离的核酸分子。 这些核酸分子参与精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供了反义核酸分子，含有代谢调控核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种代谢调节分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及培养在产生精细化学物质（例如甲硫氨酸）的条件下缺失或突变的选择的代谢调节基因的重组微生物。

    Pgro expression units
    6.
    发明授权
    Pgro expression units 有权
    Pgro表达单位

    公开(公告)号：US08728795B2

    公开(公告)日：2014-05-20

    申请号：US12038642

    申请日：2008-02-27

    申请人： Burkhard Kröger ,  Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schröder ,  Stefan Haefner

    发明人： Burkhard Kröger ,  Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schröder ,  Stefan Haefner

    IPC分类号： C12N1/21 ,  C12N15/77

    CPC分类号： C12N15/77 ,  C12P13/08

    摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。

    P EF-TU expression units
    7.
    发明授权
    P EF-TU expression units 有权
    P EF-TU表达单位

    公开(公告)号：US07785779B2

    公开(公告)日：2010-08-31

    申请号：US10582918

    申请日：2004-12-15

    申请人： Burkhard Kröger ,  Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schröder ,  Stefan Haefner

    发明人： Burkhard Kröger ,  Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schröder ,  Stefan Haefner

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K14/34 ,  C12N15/77 ,  C12P13/08 ,  C12P13/12

    摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。