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    Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis
    1.
    发明授权
    Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis 有权
    使用具有降低甲硫氨酸生物合成负调节子的表达活性的微生物生产甲硫氨酸的方法

    公开(公告)号：US08389251B2

    公开(公告)日：2013-03-05

    申请号：US13018119

    申请日：2011-01-31

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    IPC分类号： C12P13/12 ,  C12N15/74

    CPC分类号： C07K14/34

    摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，称为MR核酸分子，其涉及精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种MR分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及在产生精细化学物质例如甲硫氨酸的条件下培养具有选择的MR基因缺失或突变的重组微生物。

    CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE
    2.
    发明申请
    CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE 有权
    CORYNEBACTERIUM GLUTAMICUM GENES编码参与甲磺酸生产的法规蛋白质

    公开(公告)号：US20110229937A1

    公开(公告)日：2011-09-22

    申请号：US13018119

    申请日：2011-01-31

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    IPC分类号： C12P19/40 ,  C12P13/12 ,  C12N15/63 ,  C12P13/04

    CPC分类号： C07K14/34

    摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，称为MR核酸分子，其涉及精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种MR分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及在产生精细化学物质例如甲硫氨酸的条件下培养具有选择的MR基因缺失或突变的重组微生物。

    Nucleic acid molecules encoding metabolic regulatory proteins from Corynebacterium glutamicum, useful for increasing the production of methionone by a microorganism
    3.
    发明授权
    Nucleic acid molecules encoding metabolic regulatory proteins from Corynebacterium glutamicum, useful for increasing the production of methionone by a microorganism 失效
    编码来自谷氨酸棒杆菌的代谢调节蛋白的核酸分子，用于增加微生物产生的甲硫氨酸

    公开(公告)号：US07892798B2

    公开(公告)日：2011-02-22

    申请号：US10307138

    申请日：2002-11-29

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    IPC分类号： C12P13/12 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C07K14/34

    摘要： Isolated nucleic acid molecules, which encode novel metabolic regulatory proteins from Corynebacterium glutamicum are described. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing metabolic regulatory nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one metabolic regulatory molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected metabolic regulatory genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型代谢调节蛋白的分离的核酸分子。 这些核酸分子参与精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供了反义核酸分子，含有代谢调控核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种代谢调节分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及培养在产生精细化学物质（例如甲硫氨酸）的条件下缺失或突变的选择的代谢调节基因的重组微生物。

    Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport
    5.
    发明授权
    Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport 有权
    编码参与膜合成和膜转运的蛋白质的谷氨酸棒杆菌基因

    公开(公告)号：US06696561B1

    公开(公告)日：2004-02-24

    申请号：US09602787

    申请日：2000-06-23

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer

    IPC分类号： C12N1531

    CPC分类号： C12Q1/689 ,  C07K14/34 ,  C12N9/00 ,  C12N9/18 ,  G01N33/56911

    摘要： Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MCT蛋白质的分离的核酸分子，命名为MCT核酸分子。 本发明还提供反义核酸分子，含有MCT核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的MCT蛋白，突变的MCT蛋白，融合蛋白，抗原肽和基于该生物体中MCT基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。

    Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation
    8.
    发明授权
    Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation 有权
    编码参与体内平衡和适应的蛋白质的谷氨酸棒杆菌基因

    公开(公告)号：US06831165B1

    公开(公告)日：2004-12-14

    申请号：US09602777

    申请日：2000-06-23

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer

    IPC分类号： C07H2104

    CPC分类号： C12Q1/689 ,  C07K14/34 ,  C07K2319/00 ,  C12N9/00 ,  C12N9/18 ,  C12P13/04

    摘要： Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型HA蛋白质的分离的核酸分子，命名为HA核酸分子。 本发明还提供反义核酸分子，含有HA核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供分离的HA蛋白，突变的HA蛋白，融合蛋白，抗原肽以及用于基于该生物体中HA基因的遗传工程改进谷氨酸棒球菌产生所需化合物的方法。