发明申请
- 专利标题： Compensating for Atrioventricular Block Using a Nucleic Acid Encoding a Sodium Channel or Gap Junction Protein
- 专利标题（中）： 使用编码钠通道或间隙结蛋白的核酸补偿房室传导阻滞
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申请号： US12921395申请日： 2009-03-06
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公开(公告)号： US20110256112A2公开(公告)日： 2011-10-20
- 发明人: Ira Cohen , Peter Brink , Michael Rosen , Richard Robinson
- 申请人： Ira Cohen , Peter Brink , Michael Rosen , Richard Robinson
- 申请人地址： US NY New York 10027 US NY Albany 12207
- 专利权人： The Trustees Of Columbia University In The City Of New York,The Research Foundation of State University of New York
- 当前专利权人： The Trustees Of Columbia University In The City Of New York,The Research Foundation of State University of New York
- 当前专利权人地址： US NY New York 10027 US NY Albany 12207
- 国际申请： PCT/US2009/036420 WO 20090306
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; A61P9/00 ; A61K35/76 ; C07H21/00 ; A61K48/00 ; C12N5/10
摘要：
A method of increasing the velocity of AV conduction in a mammal that may be in heart block or at risk of heart block by causing, in an AV node and/or His bundle having less than normal conduction speed, the expression of a sodium channel or gap junction protein, such as the SkM-1 channel, Cx43 or Cx32, so as to increase the velocity of conduction by the AV node.