发明申请
- 专利标题： GAMMA SECRETASE MODULATORS
- 专利标题（中）： GAMMA秘密调节器
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申请号： US13126056申请日： 2009-11-05
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公开(公告)号： US20110257156A1公开(公告)日： 2011-10-20
- 发明人: Zhaoning Zhu , William J. Greenlee , David James Cole , Dmitri A. Pissarnitski , Gioconda V. Gallo , Hongmei Li , Hubert B. Josien , Jun Qin , Chad E. Knutson , Mihirbaran Mandal , Monica L. Vicarel , Murali Rajagopalan , Pawan Kumar Dhondi , Ruo Xu , Zhong-Yue Sun , Thomas A. Bara , Xianhai Huang , Xiaohong Zhu , Zhiqiang Zhao , John W. Clader , Anandan Palani , Theodros Asberom , Troy McCracken , Chad E. Bennett
- 申请人： Zhaoning Zhu , William J. Greenlee , David James Cole , Dmitri A. Pissarnitski , Gioconda V. Gallo , Hongmei Li , Hubert B. Josien , Jun Qin , Chad E. Knutson , Mihirbaran Mandal , Monica L. Vicarel , Murali Rajagopalan , Pawan Kumar Dhondi , Ruo Xu , Zhong-Yue Sun , Thomas A. Bara , Xianhai Huang , Xiaohong Zhu , Zhiqiang Zhao , John W. Clader , Anandan Palani , Theodros Asberom , Troy McCracken , Chad E. Bennett
- 国际申请： PCT/US09/63396 WO 20091105
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61K31/5383 ; A61K31/5377 ; A61K31/501 ; A61K31/497 ; A61K31/506 ; A61K31/438 ; A61K31/437 ; C07D413/10 ; C07D498/20 ; C07D498/04 ; A61P25/00 ; A61P25/28 ; A61K31/4245 ; A61K31/5386
摘要：
In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
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