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公开(公告)号:US20110257156A1
公开(公告)日:2011-10-20
申请号:US13126056
申请日:2009-11-05
申请人: Zhaoning Zhu , William J. Greenlee , David James Cole , Dmitri A. Pissarnitski , Gioconda V. Gallo , Hongmei Li , Hubert B. Josien , Jun Qin , Chad E. Knutson , Mihirbaran Mandal , Monica L. Vicarel , Murali Rajagopalan , Pawan Kumar Dhondi , Ruo Xu , Zhong-Yue Sun , Thomas A. Bara , Xianhai Huang , Xiaohong Zhu , Zhiqiang Zhao , John W. Clader , Anandan Palani , Theodros Asberom , Troy McCracken , Chad E. Bennett
发明人: Zhaoning Zhu , William J. Greenlee , David James Cole , Dmitri A. Pissarnitski , Gioconda V. Gallo , Hongmei Li , Hubert B. Josien , Jun Qin , Chad E. Knutson , Mihirbaran Mandal , Monica L. Vicarel , Murali Rajagopalan , Pawan Kumar Dhondi , Ruo Xu , Zhong-Yue Sun , Thomas A. Bara , Xianhai Huang , Xiaohong Zhu , Zhiqiang Zhao , John W. Clader , Anandan Palani , Theodros Asberom , Troy McCracken , Chad E. Bennett
IPC分类号: A61K31/55 , A61K31/5383 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/438 , A61K31/437 , C07D413/10 , C07D498/20 , C07D498/04 , A61P25/00 , A61P25/28 , A61K31/4245 , A61K31/5386
CPC分类号: C07D471/04 , C07D413/10 , C07D498/04 , C07D498/20 , C07F7/0812
摘要: In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了新颖的杂环化合物作为γ-分泌酶的调节剂,制备这些化合物的方法,含有一种或多种这样的化合物的药物组合物,制备包含一种或多种此类化合物的药物制剂的方法,以及治疗方法, 使用这种化合物或药物组合物预防,抑制或改善与中枢神经系统相关的一种或多种疾病。
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公开(公告)号:US08809318B2
公开(公告)日:2014-08-19
申请号:US13128316
申请日:2009-11-11
申请人: Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
发明人: Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
IPC分类号: A61K31/553 , C07D498/04 , C07D498/14 , C07D498/20
CPC分类号: C07D498/04 , C07D409/14 , C07D413/10 , C07D498/14 , C07D498/20
摘要: In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compostions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的下式杂环化合物:作为γ-分泌酶的调节剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备包含一种或多种这样的化合物的药物制剂的方法 化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与中枢神经系统相关的一种或多种疾病的方法。
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公开(公告)号:US20110306593A1
公开(公告)日:2011-12-15
申请号:US13128316
申请日:2009-11-11
申请人: Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
发明人: Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
IPC分类号: A61K31/553 , C07D498/10 , C07D498/04 , A61P25/28 , C07D413/14 , C07D498/14 , A61K31/5395 , C07D498/20 , C07D413/10
CPC分类号: C07D498/04 , C07D409/14 , C07D413/10 , C07D498/14 , C07D498/20
摘要: In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compostions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的下式杂环化合物:作为γ-分泌酶的调节剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备包含一种或多种这样的化合物的药物制剂的方法 化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与中枢神经系统相关的一种或多种疾病的方法。
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