发明申请
- 专利标题： METHODS FOR PRODUCING MIXTURES OF ANTIBODIES
- 专利标题（中）： 生产抗体混合物的方法
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申请号： US13146297申请日： 2010-01-26
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公开(公告)号： US20120020952A1公开(公告)日： 2012-01-26
- 发明人: Paul Parren , Joost J. Neijssen , Aran Frank Labrijn , Janine Schuurman , Tom Vink , Jan Van De Winkel , Stefan Loverix , Ignace Lasters
- 申请人： Paul Parren , Joost J. Neijssen , Aran Frank Labrijn , Janine Schuurman , Tom Vink , Jan Van De Winkel , Stefan Loverix , Ignace Lasters
- 申请人地址： DK Copenhagen K
- 专利权人： GENMAB A/S
- 当前专利权人： GENMAB A/S
- 当前专利权人地址： DK Copenhagen K
- 优先权： DKPA200900118 20090126
- 国际申请： PCT/EP2010/050822 WO 20100126
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C07K16/00 ; C12N5/10 ; C12P21/00 ; C12P21/02
摘要：
The invention relates to a method for producing a mixture comprising two or more different antibodies in a single recombinant host cell. In one embodiment, a mixture of different monovalent antibodies is produced. In another embodiment, a mixture of monovalent and bivalent antibodies is produced. The invention also relates to mixtures of antibodies obtainable by the method of the invention and to light chain sequences that are particularly useful in the method of the invention.
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