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公开(公告)号：US20120020952A1
公开(公告)日：2012-01-26
申请号：US13146297
申请日：2010-01-26
申请人： Paul Parren , Joost J. Neijssen , Aran Frank Labrijn , Janine Schuurman , Tom Vink , Jan Van De Winkel , Stefan Loverix , Ignace Lasters
发明人： Paul Parren , Joost J. Neijssen , Aran Frank Labrijn , Janine Schuurman , Tom Vink , Jan Van De Winkel , Stefan Loverix , Ignace Lasters
IPC分类号： A61K31/7088 , C07K16/00 , C12N5/10 , C12P21/00 , C12P21/02
CPC分类号： C07K16/00 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/626
摘要： The invention relates to a method for producing a mixture comprising two or more different antibodies in a single recombinant host cell. In one embodiment, a mixture of different monovalent antibodies is produced. In another embodiment, a mixture of monovalent and bivalent antibodies is produced. The invention also relates to mixtures of antibodies obtainable by the method of the invention and to light chain sequences that are particularly useful in the method of the invention.
摘要翻译： 本发明涉及在单个重组宿主细胞中产生包含两种或多种不同抗体的混合物的方法。 在一个实施方案中，产生不同单价抗体的混合物。 在另一个实施方案中，产生一价和二价抗体的混合物。 本发明还涉及可通过本发明的方法获得的抗体混合物和特别可用于本发明方法的轻链序列。
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2.发明申请HETERODIMERIC ANTIBODY FC-CONTAINING PROTEINS AND METHODS FOR PRODUCTION THEREOF 有权含杂交抗体的含FC蛋白质及其生产方法公开(公告)号：US20130039913A1
公开(公告)日：2013-02-14
申请号：US13642253
申请日：2011-04-20
申请人： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
发明人： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
IPC分类号： A61K39/395 , C12N5/10 , A61P35/00 , G01N33/566 , C07K16/18 , C12P21/00 , C12N15/63
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/6854
摘要： Heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
摘要翻译： 含有异二聚体抗体-Fc的蛋白质，例如双特异性抗体，以及用于产生这种蛋白质的新方法。
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3.发明授权Heterodimeric antibody Fc-containing proteins and methods for production thereof 有权含有异二聚体抗体的Fc蛋白及其制备方法公开(公告)号：US09150663B2
公开(公告)日：2015-10-06
申请号：US13642253
申请日：2011-04-20
申请人： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
发明人： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/6854
摘要： Heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
摘要翻译： 含有异二聚体抗体-Fc的蛋白质，例如双特异性抗体，以及用于产生这种蛋白质的新方法。
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公开(公告)号：US20130216548A1
公开(公告)日：2013-08-22
申请号：US13583743
申请日：2011-03-10
申请人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
发明人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
IPC分类号： C07K16/40 , A61K45/06 , A61K39/395
CPC分类号： C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
摘要： Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US09068011B2
公开(公告)日：2015-06-30
申请号：US13583743
申请日：2011-03-10
申请人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
发明人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
CPC分类号： C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
摘要： Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了结合人c-Met，肝细胞生长因子受体以及相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US20140170148A1
公开(公告)日：2014-06-19
申请号：US14112848
申请日：2012-04-20
申请人： Bart De Goeij , Patrick Van Berkel , Kristin Strumane , Aran Frank Labrijn , Joost J. Neijssen , Joyce I. Meesters , Paul Parren , Janine Schuurman
发明人： Bart De Goeij , Patrick Van Berkel , Kristin Strumane , Aran Frank Labrijn , Joost J. Neijssen , Joyce I. Meesters , Paul Parren , Janine Schuurman
IPC分类号： C07K16/32 , A61K45/06 , A61K39/395 , A61K51/10 , A61K47/48
CPC分类号： C07K16/32 , A61K45/06 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6813 , A61K47/6825 , A61K47/6827 , A61K47/6829 , A61K47/6855 , A61K47/6879 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
摘要翻译： 公开了包含与人表皮生长因子受体2（HER2）的两个不同表位结合的抗原结合区的双特异性抗体以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物和制备和使用抗体的方法。
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公开(公告)号：US20140170149A1
公开(公告)日：2014-06-19
申请号：US14112859
申请日：2012-04-20
申请人： Joost J. Neijssen , Joyce I. Meesters , Bart De Goeij , Aran Frank Labrijn , Paul Parren , Janine Schuurman
发明人： Joost J. Neijssen , Joyce I. Meesters , Bart De Goeij , Aran Frank Labrijn , Paul Parren , Janine Schuurman
摘要： Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
摘要翻译： 公开了包含与人表皮生长因子受体2（HER2）的表位结合的一个抗原结合区和与人CD3结合的一个抗原结合区以及相关的基于抗体的组合物和分子的双特异性抗体。 还公开了包含抗体的药物组合物和用于制备和使用抗体的方法。
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