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公开(公告)号：US20120020952A1
公开(公告)日：2012-01-26
申请号：US13146297
申请日：2010-01-26
申请人： Paul Parren , Joost J. Neijssen , Aran Frank Labrijn , Janine Schuurman , Tom Vink , Jan Van De Winkel , Stefan Loverix , Ignace Lasters
发明人： Paul Parren , Joost J. Neijssen , Aran Frank Labrijn , Janine Schuurman , Tom Vink , Jan Van De Winkel , Stefan Loverix , Ignace Lasters
IPC分类号： A61K31/7088 , C07K16/00 , C12N5/10 , C12P21/00 , C12P21/02
CPC分类号： C07K16/00 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/626
摘要： The invention relates to a method for producing a mixture comprising two or more different antibodies in a single recombinant host cell. In one embodiment, a mixture of different monovalent antibodies is produced. In another embodiment, a mixture of monovalent and bivalent antibodies is produced. The invention also relates to mixtures of antibodies obtainable by the method of the invention and to light chain sequences that are particularly useful in the method of the invention.
摘要翻译： 本发明涉及在单个重组宿主细胞中产生包含两种或多种不同抗体的混合物的方法。 在一个实施方案中，产生不同单价抗体的混合物。 在另一个实施方案中，产生一价和二价抗体的混合物。 本发明还涉及可通过本发明的方法获得的抗体混合物和特别可用于本发明方法的轻链序列。
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2.发明申请HETERODIMERIC ANTIBODY FC-CONTAINING PROTEINS AND METHODS FOR PRODUCTION THEREOF 有权含杂交抗体的含FC蛋白质及其生产方法公开(公告)号：US20130039913A1
公开(公告)日：2013-02-14
申请号：US13642253
申请日：2011-04-20
申请人： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
发明人： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
IPC分类号： A61K39/395 , C12N5/10 , A61P35/00 , G01N33/566 , C07K16/18 , C12P21/00 , C12N15/63
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/6854
摘要： Heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
摘要翻译： 含有异二聚体抗体-Fc的蛋白质，例如双特异性抗体，以及用于产生这种蛋白质的新方法。
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3.发明授权Heterodimeric antibody Fc-containing proteins and methods for production thereof 有权含有异二聚体抗体的Fc蛋白及其制备方法公开(公告)号：US09150663B2
公开(公告)日：2015-10-06
申请号：US13642253
申请日：2011-04-20
申请人： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
发明人： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/6854
摘要： Heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
摘要翻译： 含有异二聚体抗体-Fc的蛋白质，例如双特异性抗体，以及用于产生这种蛋白质的新方法。
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公开(公告)号：US09068011B2
公开(公告)日：2015-06-30
申请号：US13583743
申请日：2011-03-10
申请人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
发明人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
CPC分类号： C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
摘要： Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了结合人c-Met，肝细胞生长因子受体以及相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US20130216548A1
公开(公告)日：2013-08-22
申请号：US13583743
申请日：2011-03-10
申请人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
发明人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
IPC分类号： C07K16/40 , A61K45/06 , A61K39/395
CPC分类号： C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
摘要： Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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6.发明申请METHOD FOR EXTENDING THE HALF-LIFE OF EXOGENOUS OR ENDOGENOUS SOLUBLE MOLECULES 审中-公开扩增异源或内源可溶性分子半衰期的方法公开(公告)号：US20100291023A1
公开(公告)日：2010-11-18
申请号：US12602434
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
IPC分类号： A61K38/20 , A61K38/21 , A61K39/395 , C07K16/44 , C07K16/42
CPC分类号： C07K16/283 , C07K16/2812 , C07K16/2863 , C07K16/2887 , C07K2317/732
摘要： The present invention relates to methods for extending the in vivo half-life of an exogenous soluble therapeutic molecule administered to a subject, by administering to said subject the exogenous soluble molecule and a monovalent antibody that binds to the exogenous soluble molecule, as well as method for treating a disease or disorder associated with an insufficient level of an endogenous soluble molecule in a subject, by administering to said subject a monovalent antibody that binds to the endogenous soluble molecule.
摘要翻译： 本发明涉及通过向所述受试者施用外源可溶性分子和结合外源可溶性分子的单价抗体以及方法，用于延长给予受试者的外源可溶性治疗分子的体内半衰期的方法，以及方法 用于治疗与受试者内源性可溶性分子水平不足相关的疾病或病症，通过向所述受试者施用结合内源性可溶性分子的单价抗体。
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公开(公告)号：US20100105874A1
公开(公告)日：2010-04-29
申请号：US12593759
申请日：2008-03-28
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Rob Aalberse , Marijn Van Der Neut Kolfschote , Paul Parren
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Rob Aalberse , Marijn Van Der Neut Kolfschote , Paul Parren
CPC分类号： C07K16/468 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2319/00
摘要： The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding specificity which differs from said first binding specificity, wherein said second antibody comprises an IgG4-like CH3 region, c) incubating said first and second antibodies together under reducing conditions which allow the cysteines in the core hinge region to undergo disulfidebond isomerization, and d) obtaining a bispecific antibody. The invention furthermore relates to bispecific antibodies obtainable by the method of the invention.
摘要翻译： 本发明涉及用于产生双特异性抗体的离体方法，包括以下步骤：a）提供具有第一结合特异性的第一抗体，其中所述第一抗体包含IgG4样CH3区，b）提供第二抗体 具有不同于所述第一结合特异性的第二结合特异性的抗体，其中所述第二抗体包含IgG4样CH3区，c）在还原条件下将所述第一抗体和第二抗体一起温育，所述还原条件允许核心铰链区域中的半胱氨酸经历二硫键 异构化，和d）获得双特异性抗体。 本发明还涉及通过本发明的方法可获得的双特异性抗体。
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公开(公告)号：US09322035B2
公开(公告)日：2016-04-26
申请号：US12602419
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
CPC分类号： C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
摘要： The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
摘要翻译： 本发明涉及新型非人转基因动物，其在抗原刺激时能够产生结合选定抗原的单价抗体，修饰的重链转基因，用于产生非人转基因动物的方法，用于免疫非人转基因动物的方法 动物以及通过这种免疫方法可获得的单价抗体。
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公开(公告)号：US20100325744A1
公开(公告)日：2010-12-23
申请号：US12602404
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Patrick Van Berkel , Frank Beurskens
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Patrick Van Berkel , Frank Beurskens
IPC分类号： A01K67/00 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/22 , C07K16/40 , C07K16/26 , C07K16/42 , A61K39/395 , A61P35/00 , A61P29/00 , A61P37/00 , C07H21/04 , C12P21/06 , C12N1/21 , C12N5/10 , C12N1/15
CPC分类号： C07K16/00 , C07K16/2812 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/53 , C07K2317/55 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/77
摘要： The present invention provides non-glycosylated monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
摘要翻译： 本发明提供了在体内施用时具有长半衰期的非糖基化单价抗体，制备这种单价抗体的方法，包含此类抗体的药物组合物和单价抗体的用途。
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10.发明申请RECOMBINANT FUCOSE MODIFIED MONOVALENT HALF-ANTIBODIES OBTAINED BY MOLECULAR ENGINEERING 审中-公开通过分子工程获得的重组型FUCOSE修饰的单价抗体公开(公告)号：US20100255012A1
公开(公告)日：2010-10-07
申请号：US12602407
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
CPC分类号： C07K16/1063 , A61K2039/505 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/732 , C07K2317/77
摘要： Glycosylated monovalent antibodies binding to selected antigens with a low or lacking fucose content, which are capable of inducing antibody dependent cellular cytotoxicity (ADCC) on cells expressing the selected antigens in the presence of effector cells, methods for producing the monovalent antibodies, pharmaceutical compositions comprising such monovalent antibodies and use thereof for different diagnostic and therapeutic applications.
摘要翻译： 能够在效应细胞存在下表达所选抗原的细胞上诱导抗体依赖性细胞毒性（ADCC）的低或不含岩藻糖含量的选定抗原结合的糖基化单价抗体，用于产生单价抗体的方法，包含 这种单价抗体及其用于不同诊断和治疗应用。
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