发明申请
US20120021425A1 MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571
审中-公开
与STI-571相关的BCR-ABL酪氨酸激酶相关突变
- 专利标题： MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571
- 专利标题（中）： 与STI-571相关的BCR-ABL酪氨酸激酶相关突变
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申请号： US13248921申请日： 2011-09-29
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公开(公告)号： US20120021425A1公开(公告)日： 2012-01-26
- 发明人: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- 申请人： Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- 申请人地址： US CA Oakland
- 专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人地址： US CA Oakland
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/573
摘要：
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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