Invention Application
US20120040985A1 TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY
有权
用作TGR5治疗糖尿病和肥胖的激素的三唑和咪唑衍生物
- Patent Title: TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY
- Patent Title (中): 用作TGR5治疗糖尿病和肥胖的激素的三唑和咪唑衍生物
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Application No.: US13148811Application Date: 2010-02-12
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Publication No.: US20120040985A1Publication Date: 2012-02-16
- Inventor: Venkataiah Bollu , Brant Clayton Boren , Jackaline Dalgard Julien , Brenton T. Flatt , Nadia Haq , Sarah Hudson , Raju Mohan , Michael Morrissey , Benjamin Pratt , Tie-Lin Wang , Richard Martin , Xiao-Hui Gu
- Applicant: Venkataiah Bollu , Brant Clayton Boren , Jackaline Dalgard Julien , Brenton T. Flatt , Nadia Haq , Sarah Hudson , Raju Mohan , Michael Morrissey , Benjamin Pratt , Tie-Lin Wang , Richard Martin , Xiao-Hui Gu
- Applicant Address: US CA SAN FRANCISCO
- Assignee: EXELIXIS PATENT COMPANY LLC
- Current Assignee: EXELIXIS PATENT COMPANY LLC
- Current Assignee Address: US CA SAN FRANCISCO
- International Application: PCT/US10/23981 WO 20100212
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/498 ; A61K31/473 ; A61K31/423 ; A61K31/4196 ; C07D233/84 ; C07D413/06 ; C07D403/06 ; C07D403/12 ; C07D249/12 ; A61K31/4164 ; C07D405/14 ; A61P3/00 ; A61P3/04 ; A61P9/10 ; A61P3/10 ; A61P3/06 ; C12N5/02
Abstract:
The present invention comprises TGR5 agonists of structural formula I, wherein X, R1, R2, and R5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating diseases in which TGR5 is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which TGR5 is a mediator or is implicated.
Public/Granted literature
- US08785488B2 Triazole and imidazole derivatives for use as TGR5 agonists in the treatment of diabetes and obesity Public/Granted day:2014-07-22
Information query
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