发明申请
- 专利标题： NUCLEIC ACID CHEMICAL MODIFICATIONS
- 专利标题（中）： 核酸化学改性
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申请号： US13203927申请日： 2010-03-02
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公开(公告)号： US20120071641A1公开(公告)日： 2012-03-22
- 发明人: Muthiah Manoharan , Kallanthottathil G. Rajeev , Alexander V. Kelin , Sudhakar Rao Takkellapati , Shigeo Matsuda
- 申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Alexander V. Kelin , Sudhakar Rao Takkellapati , Shigeo Matsuda
- 申请人地址： US MA Cambridge
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US2010/025966 WO 20100302
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H19/167 ; C07H19/10 ; C07H19/067 ; C07H21/00 ; C07H19/20
摘要：
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
公开/授权文献
- US08975389B2 Nucleic acid chemical modifications 公开/授权日：2015-03-10
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