发明申请
- 专利标题： ANTI NOTCH-1 ANTIBODIES
- 专利标题（中）： ANTI NOTCH-1抗体
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申请号： US13378791申请日： 2010-06-16
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公开(公告)号： US20120093813A1公开(公告)日： 2012-04-19
- 发明人: Kang Li , Ping Wei , Qinghai Peng , John Andrew Lippincott , Donna Marie Stone , Zdenek Hostomsky
- 申请人： Kang Li , Ping Wei , Qinghai Peng , John Andrew Lippincott , Donna Marie Stone , Zdenek Hostomsky
- 申请人地址： US NY New York
- 专利权人： PFIZER INC
- 当前专利权人： PFIZER INC
- 当前专利权人地址： US NY New York
- 国际申请： PCT/IB2010/052711 WO 20100616
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P35/00 ; C07K16/28
摘要：
This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
公开/授权文献
- US09090690B2 Anti Notch-1 antibodies 公开/授权日：2015-07-28