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公开(公告)号:US20120093813A1
公开(公告)日:2012-04-19
申请号:US13378791
申请日:2010-06-16
申请人: Kang Li , Ping Wei , Qinghai Peng , John Andrew Lippincott , Donna Marie Stone , Zdenek Hostomsky
发明人: Kang Li , Ping Wei , Qinghai Peng , John Andrew Lippincott , Donna Marie Stone , Zdenek Hostomsky
IPC分类号: A61K39/395 , A61P35/00 , C07K16/28
CPC分类号: C07K16/28 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
摘要翻译: 本发明涉及特异性结合Notch1的单克隆抗体。 在一个实施方案中,抗体结合至少第一表位和第二表位,其中第一表位位于Notch1负调节区(NRR)的LinA结构域,第二表位位于第 Notch1 NRR。
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公开(公告)号:US09090690B2
公开(公告)日:2015-07-28
申请号:US13378791
申请日:2010-06-16
申请人: Kang Li , Ping Wei , Qinghai Peng , John Andrew Lippincott , Donna Marie Stone , Zdenek Hostomsky
发明人: Kang Li , Ping Wei , Qinghai Peng , John Andrew Lippincott , Donna Marie Stone , Zdenek Hostomsky
IPC分类号: C07K16/00 , C07K16/18 , C07K16/28 , A61K39/00 , A61K39/395 , C07K14/705
CPC分类号: C07K16/28 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
摘要翻译: 本发明涉及特异性结合Notch1的单克隆抗体。 在一个实施方案中,抗体结合至少第一表位和第二表位,其中第一表位位于Notch1负调节区(NRR)的LinA结构域,第二表位位于第 Notch1 NRR。
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