发明申请
- 专利标题： MODIFIED DEFENSINS AND THEIR USE
- 专利标题（中）： 改性防护及其使用
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申请号： US13344509申请日： 2012-01-05
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公开(公告)号： US20120107336A1公开(公告)日： 2012-05-03
- 发明人: Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
- 申请人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
- 专利权人： The Government of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services
- 当前专利权人： The Government of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61P37/04 ; A61P29/00 ; A61P11/00 ; A61P11/06 ; C12N5/071 ; A61P31/00
摘要：
This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. Methods are provided for modulating an antimicrobial activity and for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
公开/授权文献
- US08609607B2 Modified defensins and their use 公开/授权日：2013-12-17