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公开(公告)号：US20090155293A1
公开(公告)日：2009-06-18
申请号：US12388427
申请日：2009-02-18
申请人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
发明人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
CPC分类号： A61K38/1709 , C07K14/4723 , C12Q1/48 , G01N2333/4721 , G01N2500/02
摘要： This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method if provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
摘要翻译： 本公开提供了修饰的抗微生物剂，例如修饰的防御素多肽。 在一个实施方案中，提供包含修饰的精氨酸残基（例如ADP-核糖基化和/或核糖基化的α-防御素多肽）的组合物。 还提供了使用修饰的防御素多肽调节免疫应答的方法。 在一个实施方案中，提供了用于调节抗微生物活性的方法。 在另一个实施方案中，提供了用于抑制细胞毒活性的方法。 还公开了使用公开的修饰的防御素多肽来治疗受试者与免疫应答相关的疾病（例如炎症和肺部疾病）的方法。
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公开(公告)号：US08106006B2
公开(公告)日：2012-01-31
申请号：US12388427
申请日：2009-02-18
申请人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
发明人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
CPC分类号： A61K38/1709 , C07K14/4723 , C12Q1/48 , G01N2333/4721 , G01N2500/02
摘要： This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. Methods are provided for modulating an antimicrobial activity and for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
摘要翻译： 本公开提供了修饰的抗微生物剂，例如修饰的防御素多肽。 提供了包括修饰的精氨酸残基的组合物，例如ADP-核糖基化和/或核糖基化的α-防御素多肽。 还提供了使用修饰的防御素多肽调节免疫应答的方法。 提供了用于调节抗微生物活性和抑制细胞毒活性的方法。 还公开了使用公开的修饰的防御素多肽来治疗受试者与免疫应答相关的疾病（例如炎症和肺部疾病）的方法。
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公开(公告)号：US08609607B2
公开(公告)日：2013-12-17
申请号：US13344509
申请日：2012-01-05
申请人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
发明人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
CPC分类号： A61K38/1709 , C07K14/4723 , C12Q1/48 , G01N2333/4721 , G01N2500/02
摘要： This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. Methods are provided for modulating an antimicrobial activity and for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
摘要翻译： 本公开提供了修饰的抗微生物剂，例如修饰的防御素多肽。 提供了包括修饰的精氨酸残基的组合物，例如ADP-核糖基化和/或核糖基化的α-防御素多肽。 还提供了使用修饰的防御素多肽调节免疫应答的方法。 提供了用于调节抗微生物活性和抑制细胞毒活性的方法。 还公开了使用公开的修饰的防御素多肽来治疗受试者与免疫应答相关的疾病（例如炎症和肺部疾病）的方法。
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公开(公告)号：US20120107336A1
公开(公告)日：2012-05-03
申请号：US13344509
申请日：2012-01-05
申请人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
发明人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
CPC分类号： A61K38/1709 , C07K14/4723 , C12Q1/48 , G01N2333/4721 , G01N2500/02
摘要： This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. Methods are provided for modulating an antimicrobial activity and for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
摘要翻译： 本公开提供了修饰的抗微生物剂，例如修饰的防御素多肽。 提供了包括修饰的精氨酸残基的组合物，例如ADP-核糖基化和/或核糖基化的α-防御素多肽。 还提供了使用修饰的防御素多肽调节免疫应答的方法。 提供了用于调节抗微生物活性和抑制细胞毒活性的方法。 还公开了使用公开的修饰的防御素多肽来治疗受试者与免疫应答相关的疾病（例如炎症和肺部疾病）的方法。
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公开(公告)号：US07511015B2
公开(公告)日：2009-03-31
申请号：US10504838
申请日：2003-02-18
申请人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
发明人： Joel Moss , Rodney L. Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
CPC分类号： A61K38/1709 , C07K14/4723 , C12Q1/48 , G01N2333/4721 , G01N2500/02
摘要： This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method is provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
摘要翻译： 本公开提供了修饰的抗微生物剂，例如修饰的防御素多肽。 在一个实施方案中，提供包含修饰的精氨酸残基（例如ADP-核糖基化和/或核糖基化的α-防御素多肽）的组合物。 还提供了使用修饰的防御素多肽调节免疫应答的方法。 在一个实施方案中，提供了用于调节抗微生物活性的方法。 在另一个实施方案中，提供了抑制细胞毒活性的方法。 还公开了使用公开的修饰的防御素多肽来治疗受试者与免疫应答相关的疾病（例如炎症和肺部疾病）的方法。
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公开(公告)号：US20060036083A1
公开(公告)日：2006-02-16
申请号：US10504838
申请日：2003-02-18
申请人： Joel Moss , Rodney Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
发明人： Joel Moss , Rodney Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： A61K38/1709 , C07K14/4723 , C12Q1/48 , G01N2333/4721 , G01N2500/02
摘要： This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method if provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
摘要翻译： 本公开提供了修饰的抗微生物剂，例如修饰的防御素多肽。 在一个实施方案中，提供包含修饰的精氨酸残基（例如ADP-核糖基化和/或核糖基化的α-防御素多肽）的组合物。 还提供了使用修饰的防御素多肽调节免疫应答的方法。 在一个实施方案中，提供了用于调节抗微生物活性的方法。 在另一个实施方案中，提供了用于抑制细胞毒活性的方法。 还公开了使用公开的修饰的防御素多肽来治疗受试者与免疫应答相关的疾病（例如炎症和肺部疾病）的方法。
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公开(公告)号：US20080275109A1
公开(公告)日：2008-11-06
申请号：US12041550
申请日：2008-03-03
IPC分类号： A61K31/353 , C07D311/04
CPC分类号： C07D311/62 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/73 , A23V2250/2104
摘要： A drug, quasi drug, food or drink product containing a proanthocyanidine derived from hop, hop bract or apple has the effect of neutralizing or attenuating a vacuolacting toxin produced by Helicobacter pylori, thus preventing, preventing recurrence or treating digestive diseases in which Helicobacter pylori participates, as well as killing Helicobacter pylori, while providing few side effects and being free of risk of the occurrence of a tolerant strain.
摘要翻译： 含有源自啤酒花，啤酒花苞或苹果的原花青素的药物，准药物，食品或饮料产品具有中和或减弱由幽门螺杆菌产生的空泡活化毒素的作用，从而预防，预防复发或治疗幽门螺杆菌参与的消化系统疾病 ，以及杀死幽门螺杆菌，同时提供很少的副作用，并且没有发生耐受性菌株的风险。
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公开(公告)号：US20070009619A1
公开(公告)日：2007-01-11
申请号：US10574482
申请日：2004-10-04
IPC分类号： A61K31/7048 , A61K31/353 , A61K36/73
CPC分类号： C07D311/62 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/73 , A23V2250/2104
摘要： The present invention provides a drug, a quasi drug, a food or drink product having an effect of preventing, preventing recurrence or treating digestive diseases that Helicobacter pylori participates, as well as an effect of killing Helicobacter pylori while showing little side effects and being free from any risk of the occurrence of a tolerant strain. The present invention provides a drug, a quasi drug, a food or drink product containing an effective ingredient proanthocyanidines having an effect of neutralizing (attenuating) a vacuolating toxin produced by Helicobacter pylori, particularly and preferably proanthocyanidines originated from immature apple fruit or hop bracts.
摘要翻译： 本发明提供了具有预防，预防复发或治疗幽门螺杆菌参与的消化疾病的作用的药物，准药物，食品或饮料产品，以及杀死幽门螺杆菌的效果，同时显示出很少的副作用和释放 从发生耐受性菌株的任何风险。 本发明提供一种药物，准药物，食品或饮料产品，其含有有效成分原花青素，其具有中和（减毒）幽门螺杆菌产生的空泡毒素的作用，特别优选来自未成熟苹果果实或跳苞片的原花色素。
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