发明申请
- 专利标题： Inhibitors Of Bacterial Type III Secretion System
- 专利标题（中）： 细菌III型分泌系统的抑制剂
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申请号： US13263071申请日： 2010-04-06
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公开(公告)号： US20120114633A1公开(公告)日： 2012-05-10
- 发明人: Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams
- 申请人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams
- 国际申请： PCT/US10/30120 WO 20100406
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D513/04 ; C07D413/12 ; C07D265/32 ; C07C229/40 ; C07C237/20 ; C07D211/34 ; A61K31/36 ; A61K31/429 ; A61K31/5375 ; A61K31/216 ; A61K31/167 ; A61K31/4409 ; A61K39/40 ; A61P31/04 ; A61P37/04 ; A61K38/18 ; C07D317/60
摘要：
Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
公开/授权文献
- US08906945B2 Inhibitors of bacterial type III secretion system 公开/授权日：2014-12-09
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