发明申请
- 专利标题： METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DISEASES
- 专利标题（中）： 用于治疗和诊断疾病的方法和组合
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申请号： US13339833申请日： 2011-12-29
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公开(公告)号： US20120177659A1公开(公告)日： 2012-07-12
- 发明人: Steve RUBEN , Karen VAN ORDEN , Candy N. LEE , Tao HE , Mehdi MESRI , Elizabeth G. JOSELOFF , Paul MOORE , Katherine MCKINNON , Bruno DOMON
- 申请人： Steve RUBEN , Karen VAN ORDEN , Candy N. LEE , Tao HE , Mehdi MESRI , Elizabeth G. JOSELOFF , Paul MOORE , Katherine MCKINNON , Bruno DOMON
- 申请人地址： US CA Alameda
- 专利权人： CELERA CORPORATION
- 当前专利权人： CELERA CORPORATION
- 当前专利权人地址： US CA Alameda
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K14/47 ; C12N9/10 ; C12N9/12 ; C12N9/48 ; C12N9/14 ; A61K38/02 ; A61K38/17 ; A61K38/45 ; A61K38/48 ; A61K38/46 ; C07H21/04 ; C07H21/02 ; C07K16/18 ; C07K16/28 ; C07K16/40 ; C07K16/42 ; C12N5/16 ; C12N5/071 ; C12N5/09 ; G01N33/566 ; C12Q1/68 ; A61P35/00 ; C12N5/10 ; C12N1/21 ; C12N1/19 ; C07K14/705
摘要：
Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
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