-
公开(公告)号：US20120177659A1
公开(公告)日：2012-07-12
申请号：US13339833
申请日：2011-12-29
申请人： Steve RUBEN , Karen VAN ORDEN , Candy N. LEE , Tao HE , Mehdi MESRI , Elizabeth G. JOSELOFF , Paul MOORE , Katherine MCKINNON , Bruno DOMON
发明人： Steve RUBEN , Karen VAN ORDEN , Candy N. LEE , Tao HE , Mehdi MESRI , Elizabeth G. JOSELOFF , Paul MOORE , Katherine MCKINNON , Bruno DOMON
IPC分类号： A61K39/395 , C07K14/47 , C12N9/10 , C12N9/12 , C12N9/48 , C12N9/14 , A61K38/02 , A61K38/17 , A61K38/45 , A61K38/48 , A61K38/46 , C07H21/04 , C07H21/02 , C07K16/18 , C07K16/28 , C07K16/40 , C07K16/42 , C12N5/16 , C12N5/071 , C12N5/09 , G01N33/566 , C12Q1/68 , A61P35/00 , C12N5/10 , C12N1/21 , C12N1/19 , C07K14/705
CPC分类号： G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
摘要翻译： 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。
-
公开(公告)号：US20100061977A1
公开(公告)日：2010-03-11
申请号：US12504826
申请日：2009-07-17
申请人： Steve RUBEN , Karen VAN ORDEN , Candy N. LEE , Tao HE , Mehdi MESRI , Elizabeth G. JOSELOFF , Paul MOORE , Katherine MCKINNON , Bruno DOMON
发明人： Steve RUBEN , Karen VAN ORDEN , Candy N. LEE , Tao HE , Mehdi MESRI , Elizabeth G. JOSELOFF , Paul MOORE , Katherine MCKINNON , Bruno DOMON
IPC分类号： A61K39/395 , C07K14/00 , A61K38/16 , C07H21/00 , C07H21/02 , C07K16/18 , C12N5/16 , C12N5/00 , G01N33/53 , C12N7/01 , A61P35/00
CPC分类号： G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
摘要翻译： 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。
-
公开(公告)号：US20110219464A1
公开(公告)日：2011-09-08
申请号：US12868557
申请日：2010-08-25
申请人： Bruno DOMON , Elizabeth JOSELOFF , Aiqun LI , Tao HE
发明人： Bruno DOMON , Elizabeth JOSELOFF , Aiqun LI , Tao HE
IPC分类号： A01K67/00 , C12N7/01 , C12N5/10 , C12N1/00 , C12N5/071 , G01N33/566 , C12N5/12 , C07K14/47 , C07K2/00 , A61K38/17 , A61K38/02 , C07H21/00 , C07H21/02 , C07K16/18 , C07K16/42 , A61K39/395 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57423
摘要： The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung cancer (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung.
摘要翻译： 本发明提供了诊断和检测与肺相关疾病的方法。 本发明提供在肺癌（LCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合LCAT。 本发明提供LCAT作为调节LCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肺相关疾病的方法。
-
公开(公告)号：US20130067608A1
公开(公告)日：2013-03-14
申请号：US13587215
申请日：2012-08-16
申请人： Bruno DOMON , Aiqun LI , Tao HE , Ian MCCAFFERY
发明人： Bruno DOMON , Aiqun LI , Tao HE , Ian MCCAFFERY
IPC分类号： A61K39/395 , C12N15/12 , C12N15/52 , C12N15/113 , C12N5/12 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/071 , C12N5/09 , G01N33/566 , G01N33/574 , C40B30/04 , G01N33/53 , C12Q1/68 , C07K14/435 , C07K16/18 , A61K38/17 , A61P35/00 , A01K67/00 , C12N9/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/3046 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57419
摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
摘要翻译： 本发明提供了诊断和检测与结肠相关疾病的方法。 本发明提供在结肠疾病（CCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合CCAT。 本发明提供CCAT用作调节CCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与结肠相关疾病的方法。
-
公开(公告)号：US20110296544A1
公开(公告)日：2011-12-01
申请号：US13108674
申请日：2011-05-16
申请人： Bruno DOMON , Alqun Li , Tao He , Ian McCaffery
发明人： Bruno DOMON , Alqun Li , Tao He , Ian McCaffery
IPC分类号： A61K39/395 , C12N9/00 , A61K38/43 , A61K38/17 , C07H21/00 , C07H21/02 , C07K16/28 , C07K16/40 , C07K16/42 , C12N1/21 , C12N7/01 , C12N5/10 , C12N5/16 , C12N1/19 , A01K67/027 , C12N5/071 , C12N5/09 , C12Q1/68 , G01N33/53 , C40B30/04 , G01N33/566 , A61P35/00 , C07K14/705
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/3046 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57419
摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
摘要翻译： 本发明提供了诊断和检测与结肠相关疾病的方法。 本发明提供在结肠疾病（CCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合CCAT。 本发明提供CCAT用作调节CCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与结肠相关疾病的方法。
-
公开(公告)号：US20120128677A1
公开(公告)日：2012-05-24
申请号：US13100902
申请日：2011-05-04
申请人： Bruno DOMON , Ian MCCAFFERY , Vaibhav NARAYAN , Scott PATTERSON
发明人： Bruno DOMON , Ian MCCAFFERY , Vaibhav NARAYAN , Scott PATTERSON
IPC分类号： A61K39/395 , A61K38/17 , C07H21/04 , C07H21/02 , C07K16/18 , C12Q1/68 , G01N33/566 , A61P35/00 , C12N5/10 , C12N1/21 , C12N1/19 , C12N5/16 , C07K14/47 , C12N5/09
CPC分类号： G01N33/57438 , C07K14/4705 , C07K14/705 , C07K14/70503 , C07K14/70596 , C07K14/71 , C07K14/745 , C07K14/8114 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/36 , C07K16/38 , C07K16/40 , C07K16/4266 , C07K2317/24 , C07K2317/622 , C12N9/001 , C12N9/1044 , C12N9/14 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Y103/01071 , C12Y203/02013 , C12Y306/03009 , G01N2500/00 , Y10T436/25
摘要： The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAT) and antibodies binds to PCAT. The present invention provides that PCAT is used as targets for screening agents that modulates the PCAT activities. Further, the present invention provides methods for treating diseases associated with pancreas.
摘要翻译： 本发明提供了诊断和检测与胰腺相关疾病的方法。 本发明提供在胰腺疾病（PCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合PCAT。 本发明提供PCAT作为调节PCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与胰腺相关疾病的方法。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.065 秒)
