发明申请
- 专利标题： COMPOUNDS AND METHODS OF USE
- 专利标题（中）： 化合物和使用方法
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申请号： US13347364申请日： 2012-01-10
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公开(公告)号： US20120184541A1公开(公告)日： 2012-07-19
- 发明人: Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Danette A. Dudley , Wayne J. Fairbrother , John A. Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Carl Steven Rye , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Andrew M. Petros , Andrew J. Souers , Peter Czabotar
- 申请人： Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Danette A. Dudley , Wayne J. Fairbrother , John A. Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Carl Steven Rye , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Andrew M. Petros , Andrew J. Souers , Peter Czabotar
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; A61K31/519 ; A61P9/00 ; A61P35/00 ; A61P35/02 ; A61P7/02 ; A61K31/538 ; A61K31/498
摘要：
In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
公开/授权文献
- US08518970B2 Compounds and methods of use 公开/授权日：2013-08-27