发明申请
- 专利标题： Diagnostic Marker for Hepatocellular Carcinoma Comprising Anti-FASN Autoantibodies and a Diagnostic Composition for Hepatocellular Carcinoma Comprising Antigens Thereof
- 专利标题（中）： 包括抗FASN自身抗体的肝细胞癌的诊断标记和包含抗原的肝细胞癌的诊断组合物
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申请号： US13501426申请日： 2010-10-01
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公开(公告)号： US20120264147A1公开(公告)日： 2012-10-18
- 发明人: Eun Wie Cho , Chang Kyu Heo , Mi Kyung Woo , Hai Min Hwang , Hyang Sook Yoo , Jeong Heun Ko
- 申请人： Eun Wie Cho , Chang Kyu Heo , Mi Kyung Woo , Hai Min Hwang , Hyang Sook Yoo , Jeong Heun Ko
- 申请人地址： KR Daejeon
- 专利权人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 当前专利权人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 当前专利权人地址： KR Daejeon
- 优先权： KR10-2009-0096991 20091012; KR10-2010-0018205 20100226
- 国际申请： PCT/KR2010/006727 WO 20101001
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; G01N33/566 ; G01N33/561 ; C07K7/06 ; G01N33/558 ; G01N21/64 ; C07K16/40 ; C12N5/20 ; G01N33/559
摘要：
The present invention relates to an autoantibody specifically recognizing the epitope sequence of FASN (fatty acid synthase), more particularly, to the autoantibody or a fragment comprising an antigen-binding site thereof, a diagnostic composition for hepatocellular carcinoma comprising an agent capable of assessing the expression level of the autoantibody, a hybridoma cell line producing the autoantibody, a diagnostic kit for hepatocellular carcinoma comprising the composition, a method for detecting the autoantibody of hepatocellular carcinoma patient using the composition, and a method for screening a therapeutic agent for hepatocellular carcinoma by administering candidate materials for hepatocellular carcinoma treatment to confirm a reduction in the expression level of autoantibody.
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