公开(公告)号：US08658769B2

公开(公告)日：2014-02-25

申请号：US13501426

申请日：2010-10-01

申请人： Eun Wie Cho ,  Chang Kyu Heo ,  Mi Kyung Woo ,  Hai Min Hwang ,  Hyang Sook Yoo ,  Jeong Heun Ko

发明人： Eun Wie Cho ,  Chang Kyu Heo ,  Mi Kyung Woo ,  Hai Min Hwang ,  Hyang Sook Yoo ,  Jeong Heun Ko

IPC分类号： C07K16/00

CPC分类号： C07K16/40 ,  C07K2317/34 ,  G01N33/57438

摘要： The present invention relates to an autoantibody specifically recognizing the epitope sequence of FASN (fatty acid synthase), more particularly, to the autoantibody or a fragment comprising an antigen-binding site thereof, a diagnostic composition for hepatocellular carcinoma comprising an agent capable of assessing the expression level of the autoantibody, a hybridoma cell line producing the autoantibody, a diagnostic kit for hepatocellular carcinoma comprising the composition, a method for detecting the autoantibody of hepatocellular carcinoma patient using the composition, and a method for screening a therapeutic agent for hepatocellular carcinoma by administering candidate materials for hepatocellular carcinoma treatment to confirm a reduction in the expression level of autoantibody.

摘要翻译： 本发明涉及特异性识别FASN（脂肪酸合成酶）的表位序列的自身抗体，更具体地，涉及自身抗体或其抗原结合位点的片段，包括能够评估 自身抗体的表达水平，产生自身抗体的杂交瘤细胞系，包含该组合物的肝细胞癌的诊断试剂盒，使用该组合物检测肝细胞癌患者的自身抗体的方法，以及用于筛选肝细胞癌治疗剂的方法 管理候选材料进行肝细胞癌治疗以确认自身抗体表达水平的降低。

公开(公告)号：US20120264147A1

公开(公告)日：2012-10-18

申请号：US13501426

申请日：2010-10-01

申请人： Eun Wie Cho ,  Chang Kyu Heo ,  Mi Kyung Woo ,  Hai Min Hwang ,  Hyang Sook Yoo ,  Jeong Heun Ko

发明人： Eun Wie Cho ,  Chang Kyu Heo ,  Mi Kyung Woo ,  Hai Min Hwang ,  Hyang Sook Yoo ,  Jeong Heun Ko

IPC分类号： G01N33/574 ,  G01N33/566 ,  G01N33/561 ,  C07K7/06 ,  G01N33/558 ,  G01N21/64 ,  C07K16/40 ,  C12N5/20 ,  G01N33/559

CPC分类号： C07K16/40 ,  C07K2317/34 ,  G01N33/57438

摘要： The present invention relates to an autoantibody specifically recognizing the epitope sequence of FASN (fatty acid synthase), more particularly, to the autoantibody or a fragment comprising an antigen-binding site thereof, a diagnostic composition for hepatocellular carcinoma comprising an agent capable of assessing the expression level of the autoantibody, a hybridoma cell line producing the autoantibody, a diagnostic kit for hepatocellular carcinoma comprising the composition, a method for detecting the autoantibody of hepatocellular carcinoma patient using the composition, and a method for screening a therapeutic agent for hepatocellular carcinoma by administering candidate materials for hepatocellular carcinoma treatment to confirm a reduction in the expression level of autoantibody.

摘要翻译： 本发明涉及特异性识别FASN（脂肪酸合成酶）的表位序列的自身抗体，更具体地，涉及自身抗体或其抗原结合位点的片段，包括能够评估 自身抗体的表达水平，产生自身抗体的杂交瘤细胞系，包含该组合物的肝细胞癌的诊断试剂盒，使用该组合物检测肝细胞癌患者的自身抗体的方法，以及用于筛选肝细胞癌治疗剂的方法 管理候选材料进行肝细胞癌治疗以确认自身抗体表达水平的降低。