发明申请
US20120329743A1 CYCLOALKYL-FUSED TETRAHYDROQUINOLINES AS CRTH2 RECEPTOR MODULATORS
有权
作为CRTH2受体调节剂的环丙基二烯丙基四氢喹啉
- 专利标题： CYCLOALKYL-FUSED TETRAHYDROQUINOLINES AS CRTH2 RECEPTOR MODULATORS
- 专利标题（中）： 作为CRTH2受体调节剂的环丙基二烯丙基四氢喹啉
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申请号： US13523354申请日： 2012-06-14
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公开(公告)号： US20120329743A1公开(公告)日： 2012-12-27
- 发明人: Xianhai Huang , Jason Brubaker , Scott L. Peterson , John W. Butcher , Joshua T. Close , Michelle Martinez , Rachel Nicola MacCoss , Joon O. Jung , Phieng Siliphaivanh , Hongjun Zhang , Robert G. Aslanian , Purakkattle Johny Biju , Li Dong , Ying Huang , Kevin D. McCormick , Anandan Palani , Ning Shao , Wei Zhou
- 申请人： Xianhai Huang , Jason Brubaker , Scott L. Peterson , John W. Butcher , Joshua T. Close , Michelle Martinez , Rachel Nicola MacCoss , Joon O. Jung , Phieng Siliphaivanh , Hongjun Zhang , Robert G. Aslanian , Purakkattle Johny Biju , Li Dong , Ying Huang , Kevin D. McCormick , Anandan Palani , Ning Shao , Wei Zhou
- 主分类号： C07D221/16
- IPC分类号： C07D221/16 ; C07D413/10 ; A61K31/5377 ; C07D401/10 ; A61P11/00 ; A61K31/501 ; C07H15/26 ; A61K31/706 ; A61P11/06 ; A61P37/08 ; A61K31/473 ; A61K31/506
摘要：
The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
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