发明申请
- 专利标题： KINESIN INHIBITORS AS CANCER THERAPEUTICS
- 专利标题（中）： KINESIN抑制剂作为癌症治疗
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申请号： US13546713申请日： 2012-07-11
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公开(公告)号： US20130012560A1公开(公告)日： 2013-01-10
- 发明人: Tinya Abrams , Paul Barsanti , David Duhl , Michel Faure , Paul A. Renhowe , Annette Olga Walter
- 申请人： Tinya Abrams , Paul Barsanti , David Duhl , Michel Faure , Paul A. Renhowe , Annette Olga Walter
- 主分类号： A61K31/4164
- IPC分类号： A61K31/4164 ; A61P35/04 ; A61P35/02 ; A61P35/00
摘要：
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
公开/授权文献
- US08664256B2 Kinesin inhibitors as cancer therapeutics 公开/授权日：2014-03-04
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