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公开(公告)号：US09789203B2
公开(公告)日：2017-10-17
申请号：US14774512
申请日：2014-03-12
申请人： Tinya Abrams , Steven Cohen , Christie P. Fanton , Catrin Finner , Thomas Huber , Kathy Miller , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette
发明人： Tinya Abrams , Steven Cohen , Christie P. Fanton , Catrin Finner , Thomas Huber , Kathy Miller , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette
IPC分类号： A61K39/395 , A61K47/48 , A61K39/00 , C07K16/32 , C07K16/28 , A61K31/537 , A61K45/06 , A61K47/12 , A61K47/26 , A61K49/00 , A61K49/16 , A61K51/10 , A61K9/00 , A61K9/19
CPC分类号： A61K47/6803 , A61K9/0019 , A61K9/19 , A61K31/537 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/6801 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6865 , A61K47/6867 , A61K47/6889 , A61K49/00 , A61K51/103 , A61K51/1093 , A61K2039/505 , C07K16/2803 , C07K16/2863 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
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公开(公告)号：US20160137730A1
公开(公告)日：2016-05-19
申请号：US14940961
申请日：2015-11-13
申请人： Tinya ABRAMS , Steven Bruce Cohen , Jason Damiano , Clemens Dürr , Thomas Huber , Daniel Menezes , Kathy Miller , Katherine Rendahl , Jean-Michel Rene Rondeau
发明人： Tinya ABRAMS , Steven Bruce Cohen , Jason Damiano , Clemens Dürr , Thomas Huber , Daniel Menezes , Kathy Miller , Katherine Rendahl , Jean-Michel Rene Rondeau
IPC分类号： C07K16/28 , G01N33/574 , A61K47/48 , C07K16/30 , A61K31/5365
CPC分类号： C07K16/28 , A61K31/5365 , A61K47/6803 , A61K47/6849 , A61K47/6851 , C07K16/30 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/57492 , G01N2333/705
摘要： This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
摘要翻译： 本申请公开了抗P-钙粘蛋白抗体，其抗原结合片段和所述抗体或抗原结合片段的抗体药物偶联物。 本发明还涉及使用抗体，抗原结合片段和抗体药物缀合物治疗癌症的方法。 本文还公开了制备抗体，抗原结合片段和抗体药物缀合物的方法，以及使用抗体和抗原结合片段作为诊断试剂的方法。
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公开(公告)号：US08735599B2
公开(公告)日：2014-05-27
申请号：US13613977
申请日：2012-09-13
申请人： Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人： Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号： A61K31/4174 , C07D233/00 , C07D233/54
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。 本发明的化合物具有以下通式：
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公开(公告)号：US20170035905A1
公开(公告)日：2017-02-09
申请号：US15284444
申请日：2016-10-03
申请人： Tinya Abrams , Steven Bruce Cohen , Christie P. Fanton , Thomas Huber , Kathy Miller , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette , Catrin Finner
发明人： Tinya Abrams , Steven Bruce Cohen , Christie P. Fanton , Thomas Huber , Kathy Miller , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette , Catrin Finner
CPC分类号： A61K47/6803 , A61K9/0019 , A61K9/19 , A61K31/537 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/6801 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6865 , A61K47/6867 , A61K47/6889 , A61K49/00 , A61K51/103 , A61K51/1093 , A61K2039/505 , C07K16/2803 , C07K16/2863 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
摘要翻译： 本发明涉及抗cKIT抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。
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公开(公告)号：US20160030594A1
公开(公告)日：2016-02-04
申请号：US14774512
申请日：2014-03-12
申请人： Tinya ABRAMS , Steven COHEN , Christie P. FANTON , Catrin FINNER , Thomas HUBER , Kathy MILLER , Siew Ho SCHLEYER , Kathrin Ulrike TISSOT-DAGUETTE
发明人： Tinya ABRAMS , Steven COHEN , Christie P. FANTON , Catrin FINNER , Thomas HUBER , Kathy MILLER , Siew Ho SCHLEYER , Kathrin Ulrike TISSOT-DAGUETTE
CPC分类号： A61K47/6803 , A61K9/0019 , A61K9/19 , A61K31/537 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/6801 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6865 , A61K47/6867 , A61K47/6889 , A61K49/00 , A61K51/103 , A61K51/1093 , A61K2039/505 , C07K16/2803 , C07K16/2863 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
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公开(公告)号：US08252832B2
公开(公告)日：2012-08-28
申请号：US12313923
申请日：2008-11-25
申请人： Tinya Abrams , Paul Barsanti , David Duhl , Michel Faure , Paul A. Renhowe , Annette Olga Walter
发明人： Tinya Abrams , Paul Barsanti , David Duhl , Michel Faure , Paul A. Renhowe , Annette Olga Walter
IPC分类号： A61K31/4174 , C07D233/64
CPC分类号： A61K31/4164 , C07D233/61
摘要： The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
摘要翻译： 本发明提供了具有取代的咪唑环的新化合物，以及使用这些化合物治疗某些疾病如血液癌和实体瘤的方法。 本发明的化合物是抑制KSP的三取代的咪唑衍生物。 这些化合物也可用于治疗药物抗性肿瘤，例如表达升高的P-糖蛋白水平的实体瘤。
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公开(公告)号：US20110256128A1
公开(公告)日：2011-10-20
申请号：US13085746
申请日：2011-04-13
申请人： Tinya ABRAMS , Paul A. BARSANTI , Yu DING , David DUHL , Wooseok HAN , Cheng HU , Yue PAN
发明人： Tinya ABRAMS , Paul A. BARSANTI , Yu DING , David DUHL , Wooseok HAN , Cheng HU , Yue PAN
IPC分类号： A61K31/4196 , C07D413/12 , A61K31/5377 , A61P35/02 , A61K33/24 , A61K31/7068 , A61P35/00 , A61K31/661 , C07D407/12 , A61K39/395
CPC分类号： C07D403/12 , A61K31/4196 , A61K31/5377 , A61K45/06 , C07D207/10 , C07D249/08 , C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention provides triazole compounds of Formula I: as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula I.
摘要翻译： 本发明提供式I的三唑化合物：如本文进一步描述的。 本发明还提供了包含治疗有效量的式I化合物的药物组合物，以及治疗在哺乳动物患者中至少部分地由KSP介导的病症的方法，包括向需要这种治疗的哺乳动物患者施用 治疗有效量的式I化合物。
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公开(公告)号：US20190119375A1
公开(公告)日：2019-04-25
申请号：US15988659
申请日：2018-05-24
申请人： Tinya Abrams , Steven Bruce Cohen , Jason Damiano , Clemens Dürr , Thomas Huber , Daniel Menezes , Kathy Miller , Katherine Rendahl , Jean-Michel Rene Rondeau
发明人： Tinya Abrams , Steven Bruce Cohen , Jason Damiano , Clemens Dürr , Thomas Huber , Daniel Menezes , Kathy Miller , Katherine Rendahl , Jean-Michel Rene Rondeau
IPC分类号： C07K16/28 , A61K47/68 , C07K16/30 , A61K31/5365 , G01N33/574
摘要： This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
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公开(公告)号：US20140271688A1
公开(公告)日：2014-09-18
申请号：US14205915
申请日：2014-03-12
申请人： Tinya Abrams , Steven Bruce Cohen , Christie P. Fanton , Thomas Huber , Kathy Miller , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette , Catrin Finner
发明人： Tinya Abrams , Steven Bruce Cohen , Christie P. Fanton , Thomas Huber , Kathy Miller , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette , Catrin Finner
IPC分类号： A61K47/48 , A61K51/10 , A61K49/00 , A61K39/395
CPC分类号： A61K47/6803 , A61K9/0019 , A61K9/19 , A61K31/537 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/6801 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6865 , A61K47/6867 , A61K47/6889 , A61K49/00 , A61K51/103 , A61K51/1093 , A61K2039/505 , C07K16/2803 , C07K16/2863 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
摘要翻译： 本发明涉及抗cKIT抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。
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公开(公告)号：US08664256B2
公开(公告)日：2014-03-04
申请号：US13546713
申请日：2012-07-11
申请人： Tinya Abrams , Paul A. Barsanti , David Duhl , Michel Faure , Paul A. Renhowe , Annette Olga Walter
发明人： Tinya Abrams , Paul A. Barsanti , David Duhl , Michel Faure , Paul A. Renhowe , Annette Olga Walter
IPC分类号： A61K31/4164
CPC分类号： A61K31/4164 , C07D233/61
摘要： The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
摘要翻译： 本发明提供了具有取代的咪唑环的新化合物，以及使用这些化合物治疗某些疾病如血液癌和实体瘤的方法。 本发明的化合物是抑制KSP的三取代的咪唑衍生物。 这些化合物也可用于治疗药物抗性肿瘤，例如表达升高的P-糖蛋白水平的实体瘤。
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