公开(公告)号：US08962713B2

公开(公告)日：2015-02-24

申请号：US13256331

申请日：2010-03-23

Applicant: Jean-Michel Faure ,  Olivier Watt ,  David Rinaldi ,  Hakimi Yahiaoui

Inventor： Jean-Michel Faure ,  Olivier Watt ,  David Rinaldi ,  Hakimi Yahiaoui

IPC: C04B24/26 ,  C04B24/24 ,  C04B28/14 ,  C04B103/40 ,  C04B111/00

CPC classification number: C04B24/246 ,  C04B28/14 ,  C04B2103/408 ,  C04B2111/0062 ,  C04B38/10 ,  C04B2103/22

Abstract: A method includes using copolymers including at least polyoxyalkylenated monomer units and at least phosphorus-comprising monomer units as water-reducing agent in hydraulic binders.

Abstract translation: 一种方法包括在水硬性粘合剂中使用包含至少聚氧化烯化的单体单元和至少含磷的单体单元作为减水剂的共聚物。

公开(公告)号：US08729160B2

公开(公告)日：2014-05-20

申请号：US12747305

申请日：2008-12-12

Applicant: Jean-Michel Faure ,  David Rinaldi ,  Horacio Naranjo

Inventor： Jean-Michel Faure ,  David Rinaldi ,  Horacio Naranjo

IPC: C08B31/12 ,  C08K3/00

CPC classification number: C04B24/2647 ,  C04B28/145 ,  C04B28/16 ,  C04B2103/22 ,  C04B2103/32

Abstract: A method includes adding at least one copolymer or a salt thereof acting as a plasticizer, blocking agent, or both a plasticizer and a blocking agent, to a calcium sulphate-based hydraulic binder. The copolymer includes an acrylic acid or a poly(oxy)alkylene copolymer.

Abstract translation: 一种方法包括将至少一种作为增塑剂，阻聚剂或增塑剂和封闭剂两者的共聚物或其盐加入硫酸钙基水硬性粘合剂中。 共聚物包括丙烯酸或聚（氧）亚烷基共聚物。

公开(公告)号：US08664256B2

公开(公告)日：2014-03-04

申请号：US13546713

申请日：2012-07-11

Applicant: Tinya Abrams ,  Paul A. Barsanti ,  David Duhl ,  Michel Faure ,  Paul A. Renhowe ,  Annette Olga Walter

Inventor： Tinya Abrams ,  Paul A. Barsanti ,  David Duhl ,  Michel Faure ,  Paul A. Renhowe ,  Annette Olga Walter

IPC: A61K31/4164

CPC classification number: A61K31/4164 ,  C07D233/61

Abstract: The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.

Abstract translation: 本发明提供了具有取代的咪唑环的新化合物，以及使用这些化合物治疗某些疾病如血液癌和实体瘤的方法。 本发明的化合物是抑制KSP的三取代的咪唑衍生物。 这些化合物也可用于治疗药物抗性肿瘤，例如表达升高的P-糖蛋白水平的实体瘤。

公开(公告)号：US08288087B2

公开(公告)日：2012-10-16

申请号：US12375074

申请日：2007-07-26

Applicant: Nguyen Tan ,  Eleni Venetsanakos ,  Michel Faure ,  Carla Heise

Inventor： Nguyen Tan ,  Eleni Venetsanakos ,  Michel Faure ,  Carla Heise

IPC: G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574

CPC classification number: A61K31/4439 ,  A61K31/44 ,  A61K31/496 ,  G01N33/5743 ,  G01N2333/4704 ,  G01N2500/10

Abstract: The present invention provides a method for determining a response of a mammalian subject having melanoma tumor cells to treatment with a melanoma inhibitory agent. In one aspect, the method comprises (a) determining a first concentration of melanoma inhibitory activity protein (MIA) in a first biological sample taken from the mammalian subject before treatment with the melanoma inhibitory agent; (b) determining a second concentration of MIA in a second biological sample from the mammalian subject taken after treatment with the melanoma inhibitory agent; and (c) comparing the first and second concentrations of MIA, wherein a decrease in the second concentration of MIA measured in the second biological sample as compared to the first concentration of MIA measured in the first biological sample indicates a positive response to the treatment with the melanoma inhibitory agent.

Abstract translation: 本发明提供了一种确定具有黑素瘤肿瘤细胞的哺乳动物受试者用黑素瘤抑制剂治疗的反应的方法。 一方面，该方法包括：（a）在用黑素瘤抑制剂处理之前，从取自哺乳动物受试者的第一生物样品中确定黑素瘤抑制活性蛋白（MIA）的第一浓度; （b）在用黑素瘤抑制剂处理后，确定来自哺乳动物受试者的第二生物样品中MIA的第二浓度; 和（c）比较第一和第二浓度的MIA，其中在第二生物样品中测量的MIA的第二浓度的降低与在第一生物样品中测量的MIA的第一浓度相比表明对于用 黑素瘤抑制剂。

公开(公告)号：US20110042163A1

公开(公告)日：2011-02-24

申请号：US12936686

申请日：2009-04-21

Applicant: Florence Serre ,  Rita Faddoul ,  Jean-Michel Faure ,  Claude Stock

Inventor： Florence Serre ,  Rita Faddoul ,  Jean-Michel Faure ,  Claude Stock

IPC: E04B1/82 ,  C08J9/00

CPC classification number: C04B26/06 ,  C04B26/02 ,  C04B2111/00267 ,  C04B2111/00482 ,  C04B2111/0062 ,  C04B2111/00827 ,  C04B2111/52 ,  Y02W30/97 ,  C04B14/28 ,  C04B16/0691 ,  C04B20/0076 ,  C04B38/10 ,  C04B2103/44 ,  C04B14/305 ,  C04B18/24 ,  C04B24/38 ,  C04B2103/408

Abstract: A finishing compound having acoustic properties and including iii percentage by weight relative to the total weight of the product, at least 10 to 70% of water; 0.1 to 5% of a foaming agent; 0.1 to 5% of a thickening agent; 35 to 70% of a monogranular filler having a size greater than or equal to 100 μm and excluding fine fillers; 0.1 to 8% of synthetic or animal fibres; 0.5 to 35% of binder.

Abstract translation: 具有声学性能并且包括相对于产品的总重量的iii重量百分比的整理化合物，至少10至70％的水; 0.1〜5％的发泡剂; 0.1〜5％的增稠剂; 35〜70％的粒径大于或等于100μm的单颗粒填料，不含细填料; 0.1〜8％的合成纤维或动物纤维; 0.5〜35％的粘合剂。

公开(公告)号：US20050276757A1

公开(公告)日：2005-12-15

申请号：US11128106

申请日：2005-05-11

Applicant: Jocelyn Wright ,  Victoria Sung ,  Michel Faure ,  Elizabeth Blackwood

Inventor： Jocelyn Wright ,  Victoria Sung ,  Michel Faure ,  Elizabeth Blackwood

IPC: A61K49/00 ,  A61P35/00 ,  C12Q1/48 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/485 ,  A61K49/0004 ,  G01N33/574 ,  G01N2500/02 ,  G01N2800/52

Abstract: The present invention provides novel biomarkers for cancer: the phosphorylation of ZC1 and/or ZC3 kinase substrates, particularly p120 catenin and Abi-1. Accordingly, the invention provides methods of determining whether a compound modulates ZC1 or ZC3 kinase activity, methods of determining whether a mammal is responding to a compound that modulates ZC1 or ZC3 kinase activity, and methods of predicting whether a mammal will respond therapeutically to a method of treating cancer by administering a modulator of ZC1 or ZC3 kinase.

Abstract translation: 本发明提供新的癌症生物标志物：ZC1和/或ZC3激酶底物的磷酸化，特别是p120连环蛋白和Abi-1。 因此，本发明提供了确定化合物是否调节ZC1或ZC3激酶活性的方法，确定哺乳动物是否对调节ZC1或ZC3激酶活性的化合物作出反应的方法以及预测哺乳动物是否会对方法进行治疗的方法 通过施用ZC1或ZC3激酶的调节剂治疗癌症。

公开(公告)号：US5886311A

公开(公告)日：1999-03-23

申请号：US927928

申请日：1997-09-11

Applicant: Robert Morel ,  Henri Auque ,  Philippe Hartmann ,  Denis Vial ,  Michel Faure

Inventor： Robert Morel ,  Henri Auque ,  Philippe Hartmann ,  Denis Vial ,  Michel Faure

IPC: H01H1/36 ,  H01H3/40 ,  H01H9/00 ,  H01H19/64 ,  H01H21/18 ,  H01H21/42 ,  H01H3/32

CPC classification number: H01H21/18 ,  H01H19/64 ,  H01H9/0072 ,  H01H1/2041 ,  H01H1/365 ,  H01H2071/1036 ,  H01H21/42 ,  H01H3/40

Abstract: A multipole switch comprises a plurality of single-pole switch modules arranged side by side in compartments of the insulating case. Each switch module comprises an individual switching bar supporting the movable contact, said bar being formed by a vertical-axis rotary insulating stud having an end-piece for guiding in rotation at one of its ends, and driving means at the other end. A pair of actuating rods is mechanically coupled to the driving means of all the switching bars, and cooperates with connecting rods of the operating mechanism to perform movement of the actuating rods in translation in opposite directions when moving from the open position to the closed position, and vice-versa, said elongate actuating rods extending parallel to one another in a horizontal plane perpendicular to the different rotary studs.

Abstract translation: 多极开关包括在绝缘壳体的隔室中并排布置的多个单极开关模块。 每个开关模块包括支撑可动触头的单独的开关杆，所述杆由垂直轴旋转绝缘支柱形成，所述垂直轴旋转绝缘支架具有用于在其一端引导旋转的端件和另一端的驱动装置。 一对致动杆机械联接到所有切换杆的驱动装置，并且与操作机构的连接杆配合，以在从打开位置移动到关闭位置时沿相反方向平移的致动杆的运动， 并且反之亦然，所述细长致动杆在垂直于不同旋转螺柱的水平面中彼此平行延伸。

公开(公告)号：US4465325A

公开(公告)日：1984-08-14

申请号：US415348

申请日：1982-09-07

Applicant: Michel Faure ,  Jean-Louis Poinssot

Inventor： Michel Faure ,  Jean-Louis Poinssot

IPC: F16C29/02 ,  G21C19/02 ,  F16C32/06 ,  G21C19/00

CPC classification number: F16C32/06 ,  F16C29/025 ,  G21C19/02

Abstract: The present invention relates to a device for handling a load, particularly an immersed load, by means of a shaft having a polygonal cross-section.The shaft, which can move along its axis, is maintained by a bearing connected to rotation means, so that a rotation of the bearing about the axis of the shaft leads to an identical rotation of the latter. The supply fluid for the bearing can be that in which the load to be manipulated is immersed.Application to the control and inspection of fuel rods.

Abstract translation: 本发明涉及一种用于通过具有多边形横截面的轴来处理负载，特别是浸入式负载的装置。 可以沿其轴线移动的轴由连接到旋转装置的轴承保持，使得轴承围绕轴的轴线的旋转导致其相同的旋转。 用于轴承的供应流体可以是要操纵的负载被浸没的供应流体。 应用于燃料棒的控制和检查。

公开(公告)号：US4457770A

公开(公告)日：1984-07-03

申请号：US364251

申请日：1982-04-01

Applicant: Michel Faure ,  Yves Lumineau ,  Andre Jouanin

Inventor： Michel Faure ,  Yves Lumineau ,  Andre Jouanin

IPC: C03B37/018 ,  C03B37/025

CPC classification number: C03B37/01807

Abstract: The invention relates to an apparatus for producing a preform for constituting an optical fiber. This apparatus essentially comprises a glass maker's lathe and a motor which holds and rotates a hollow silica tube, a torch making it possible to heat a cross-section of the tube and which can be translated along the tube and means for supplying the gaseous compounds consisting of silicon chloride, oxygen and doping agents decomposing under the action of the heat. Part of the products obtained is deposited on the walls of the tube. The supply means comprise a pipe entering the tube in axial manner and at the end of which are provided two radially directed arms, which terminate with an outlet normal to the pipe and arm, said pipe moving in translation integrally with the torch.

Abstract translation: 本发明涉及一种用于制造用于构成光纤的预成型件的设备。 该设备基本上包括玻璃制造商的车床和电动机，其保持和旋转中空二氧化硅管，火炬使得可以加热管的横截面并且可以沿着管平移并且用于供应气态化合物的装置 的氯化硅，氧气和掺杂剂在热的作用下分解。 获得的部分产品沉积在管的壁上。 供应装置包括以轴向方式进入管的管，并且其末端设置有两个径向指向的臂，其终止于与管和臂垂直的出口，所述管与火炬一体地移动。

公开(公告)号：US4249924A

公开(公告)日：1981-02-10

申请号：US42785

申请日：1979-05-29

Applicant: Arnaud de Panafieu ,  Christiane Baylac ,  Yves Nemaud ,  Marc Turpin ,  Michel Faure

Inventor： Arnaud de Panafieu ,  Christiane Baylac ,  Yves Nemaud ,  Marc Turpin ,  Michel Faure

IPC: C03B37/014 ,  C03C3/089 ,  C03C13/04 ,  C03C15/00 ,  C03C23/00 ,  G02B6/00 ,  G02B6/028 ,  C03B37/00 ,  C03B32/00

CPC classification number: G02B6/0281 ,  C03C13/045 ,  C03C13/046 ,  C03C15/00 ,  C03C23/008

Abstract: A process for the manufacture of a glass blank in the form of a rod from which the optical fibre is drawn, said blank being produced starting from a molten bath of glass. A first stage of the process comprises melting a mixture of starting materials having a higher impurity content (

Abstract translation: 一种用于制造呈玻璃形状的玻璃坯料的方法，从该玻璃坯料中拉出光纤，所述坯料从玻璃熔池开始产生。 该方法的第一阶段包括将所谓的过渡金属形式的杂质含量（<10-4）的原料混合物熔化成最后的坯料（<10-7）。 第二阶段是通过从熔融玻璃浴中抽出坯料并随后对其进行热退火处理，从而诱导分离成两个固相（富含二氧化硅的硬相和二氧化硅中的软相）。 接下来是深蚀刻和周边蚀刻，以消除作为深度的函数的不同程度的软相和其杂质，产生径向折射率梯度和光学包层。