- 专利标题: Fused substituted aminopyrrolidine derivative
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申请号: US12459612申请日: 2009-07-02
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公开(公告)号: US20130029977A9公开(公告)日: 2013-01-31
- 发明人: Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
- 申请人: Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
- 专利权人: Daiichi Sankyo Company, Limited
- 当前专利权人: Daiichi Sankyo Company, Limited
- 优先权: JP2007-000667 20070105; JP2007-074991 20070322
- 主分类号: A61K31/4709
- IPC分类号: A61K31/4709 ; C07D498/06 ; A61K31/5383 ; A61P1/12 ; A61P29/00 ; A61P31/04 ; A61P31/00 ; A61P33/00 ; A61P17/00 ; A61P15/00 ; A61P17/10 ; A61P11/08 ; A61P11/00 ; A61P13/08 ; A61P13/02 ; A61P27/02 ; A61P1/02 ; A61P37/00 ; A61P31/06 ; A61P31/08 ; C07D401/10
摘要:
A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.
公开/授权文献
- US08618094B2 Fused substituted aminopyrrolidine derivative 公开/授权日:2013-12-31
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