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公开(公告)号：US08618094B2
公开(公告)日：2013-12-31
申请号：US12459612
申请日：2009-07-02
申请人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
发明人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
IPC分类号： C07D401/10 , C07D498/06 , A61K31/4709 , A61K31/5383
CPC分类号： C07D498/06 , C07D209/02 , C07D209/56 , C07D401/04 , C07D401/14 , C07D491/048 , C07D491/052 , Y02P20/55
摘要： A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.
摘要翻译： 提供了作为药物具有优异性能的喹诺酮合成抗菌剂，其不仅对革兰氏阴性菌具有很强的抗菌活性，而且对喹诺酮类抗菌剂具有低敏感性的革兰氏阳性球菌具有很强的抗菌活性，并且其表现出高安全性和优异的药代动力学 。 由式（I）表示的化合物或其盐或其水合物。 具体地，其中取代基R6和R7与它们所键合的碳原子一起形成式（I）的喹诺酮衍生物形成可以含有氧原子作为环组成原子的环状结构，所述环状结构形成5- 4,5,5-或5-6稠合双环吡咯烷基取代基，该取代基与含有吡啶并苯并恶嗪结构的喹诺酮母体骨架Q结合。
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公开(公告)号：US20130029977A9
公开(公告)日：2013-01-31
申请号：US12459612
申请日：2009-07-02
申请人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
发明人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
IPC分类号： A61K31/4709 , C07D498/06 , A61K31/5383 , A61P1/12 , A61P29/00 , A61P31/04 , A61P31/00 , A61P33/00 , A61P17/00 , A61P15/00 , A61P17/10 , A61P11/08 , A61P11/00 , A61P13/08 , A61P13/02 , A61P27/02 , A61P1/02 , A61P37/00 , A61P31/06 , A61P31/08 , C07D401/10
CPC分类号： C07D498/06 , C07D209/02 , C07D209/56 , C07D401/04 , C07D401/14 , C07D491/048 , C07D491/052 , Y02P20/55
摘要： A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.
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公开(公告)号：US20120108582A1
公开(公告)日：2012-05-03
申请号：US12459612
申请日：2009-07-02
申请人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
发明人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
IPC分类号： A61K31/4709 , C07D498/06 , A61K31/5383 , A61P1/12 , A61P29/00 , A61P31/04 , A61P31/00 , A61P33/00 , A61P17/00 , A61P15/00 , A61P17/10 , A61P11/08 , A61P11/00 , A61P13/08 , A61P13/02 , A61P27/02 , A61P1/02 , A61P37/00 , A61P31/06 , A61P31/08 , C07D401/10
CPC分类号： C07D498/06 , C07D209/02 , C07D209/56 , C07D401/04 , C07D401/14 , C07D491/048 , C07D491/052 , Y02P20/55
摘要： A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.
摘要翻译： 提供了作为药物具有优异性能的喹诺酮合成抗菌剂，其不仅对革兰氏阴性菌具有很强的抗菌活性，而且对喹诺酮类抗菌剂具有低敏感性的革兰氏阳性球菌具有很强的抗菌活性，并且其表现出高安全性和优异的药代动力学 。 由式（I）表示的化合物或其盐或其水合物。 具体地，其中取代基R6和R7与它们所键合的碳原子一起形成式（I）的喹诺酮衍生物形成可以含有氧原子作为环组成原子的环状结构，所述环状结构形成5- 4,5,5-或5-6稠合双环吡咯烷基取代基，该取代基与含有吡啶并苯并恶嗪结构的喹诺酮母体骨架Q结合。
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公开(公告)号：US20120329791A1
公开(公告)日：2012-12-27
申请号：US13529459
申请日：2012-06-21
申请人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Kenichi Yoshida , Takanori Yamazaki , Takahiro Kitamura , Takeshi Isoyama
发明人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Kenichi Yoshida , Takanori Yamazaki , Takahiro Kitamura , Takeshi Isoyama
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/04 , A61K31/537 , C07D498/08 , A61K31/4375 , A61K31/496
CPC分类号： C07D471/04 , C07D451/02 , C07D491/08 , C07D498/08
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及取代的咪唑并吡啶基 - 氨基吡啶化合物和合成这些化合物的方法。 本发明还涉及含有取代的咪唑并吡啶基 - 氨基吡啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。
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公开(公告)号：US08609688B2
公开(公告)日：2013-12-17
申请号：US13529459
申请日：2012-06-21
申请人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Kenichi Yoshida , Takanori Yamazaki , Takahiro Kitamura , Takeshi Isoyama
发明人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Kenichi Yoshida , Takanori Yamazaki , Takahiro Kitamura , Takeshi Isoyama
IPC分类号： A01N43/42 , A61K31/44 , C07D515/02
CPC分类号： C07D471/04 , C07D451/02 , C07D491/08 , C07D498/08
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US09815418B2
公开(公告)日：2017-11-14
申请号：US14891171
申请日：2013-05-15
CPC分类号： B60R13/02 , B32B3/04 , B32B3/30 , B32B7/02 , B32B27/06 , B32B2307/51 , B32B2605/00
摘要： Numerous fine projections (20) are formed interspersed on a plate-shape member (18), and the neutral plane (S) of each fine projection (20) is inclined at an inclination angle α to the normal line (O) such that the contact center (Q) does not overlap with the base part in the plane direction of the surface (22), so when a pressing load (F) is applied, the moment acting on the fine projections (20) is large, and the fine projections (20) easily deform to bend in the respective inclination direction. By this means, the tactile softness (cushion properties) are improved by preventing the fine projections (20) from undergoing simple compression deformation in the axial direction, and stick-slip due to friction between the fine projections (20) and the surface (22) is avoided, making it possible to obtain a smooth and stable tactile softness.
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公开(公告)号：US09802383B2
公开(公告)日：2017-10-31
申请号：US14915738
申请日：2013-09-13
IPC分类号： B32B3/30 , B60R13/02 , B32B5/02 , B32B5/24 , B32B25/18 , B32B27/08 , B32B27/12 , B32B27/30 , B32B27/32 , B32B27/36 , B32B3/06 , B32B3/12
CPC分类号： B32B3/30 , B32B3/06 , B32B3/12 , B32B5/024 , B32B5/026 , B32B5/24 , B32B25/18 , B32B27/08 , B32B27/12 , B32B27/304 , B32B27/308 , B32B27/32 , B32B27/36 , B32B2250/03 , B32B2307/412 , B32B2307/51 , B32B2307/546 , B32B2307/706 , B32B2605/003 , B60R13/0243
摘要： A laminated composite interior component, having cushioning property, including a first member having a predetermined mating surface, and a second member made of an elastically deformable resin material, having a plate portion on and parallel to the mating surface and multiple solid protrusions formed integrally with the plate portion and having tip ends that protrude toward and contact the mating surface, and flexural rigidity of each protrusion against a compressive load having anisotropy around an axis perpendicular to the plate portion. Each of the protrusions have a longitudinal shape in a transverse section parallel to the plate portion and have one or more stepped portions, with a smaller section at its tip end side, in one of a pair of sidewalls located in a lateral direction perpendicular to a longitudinal direction of the longitudinal shape. Each protrusion is tilted toward a sidewall opposite the stepped portion.
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![Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds](/abs-image/US/2013/10/29/US08569331B2/abs.jpg.150x150.jpg)
8.发明授权Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds 有权取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物公开(公告)号：US08569331B2
公开(公告)日：2013-10-29
申请号：US13286294
申请日：2011-11-01
申请人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
发明人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
IPC分类号： A61K31/44
CPC分类号： C07D471/14 , A61K31/551 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物和合成这些化合物的方法。 本发明还涉及含有取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物的药物组合物和治疗细胞增殖性疾病如癌症的方法， 将这些化合物和药物组合物给予需要的受试者。
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公开(公告)号：US08222753B2
公开(公告)日：2012-07-17
申请号：US12379463
申请日：2009-02-23
申请人： Kenichi Yoshida , Toshiyuki Suzuki
发明人： Kenichi Yoshida , Toshiyuki Suzuki
CPC分类号： H02K9/06 , F02B63/04 , F02B63/042 , H02K3/47 , H02K7/1815 , H02K11/048 , H02K21/24
摘要： A general purpose engine is provided with an engine main body, a rotary shaft, and an axial gap type motor/generator. The rotary shaft is rotated by a driving force of the engine main body. The rotary shaft includes a first shaft part disposed on one side portion of the engine main body and a second shaft part disposed on another side portion of the engine main body. The axial gap type motor/generator is attached integrally to the second shaft part. The axial gap type motor/generator is provided with a power generating rotor that rotates integrally with said rotary shaft, and a stator that is attached to the engine main body. The stator is disposed on a side closer to the engine main body than the power generating rotor and at a remove from the power generating rotor.
摘要翻译： 通用发动机设置有发动机主体，旋转轴和轴向间隙型电动机/发电机。 旋转轴由发动机主体的驱动力旋转。 旋转轴包括设置在发动机主体的一侧部的第一轴部和设置在发动机主体的另一侧部的第二轴部。 轴向间隙型马达/发电机与第二轴部一体地安装。 轴向间隙型马达/发电机具有与所述旋转轴一体地旋转的发电转子和附接到发动机主体的定子。 定子配置在比发电用转子更靠近发动机主体的一侧并与发电转子相脱离。
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公开(公告)号：US08143757B2
公开(公告)日：2012-03-27
申请号：US12379408
申请日：2009-02-20
申请人： Kenichi Yoshida , Toshiyuki Suzuki
发明人： Kenichi Yoshida , Toshiyuki Suzuki
CPC分类号： H02K7/1815 , H02K9/06 , H02K11/048 , H02K21/24
摘要： The present invention achieves reductions in the weight and size of a general purpose engine provided for a power generation application. An optional external apparatus can be attached to one shaft part of a rotary shaft, and an axial gap type motor/generator constituted by a power generating rotor (inner rotor) and a stator is attached integrally to another shaft part of the rotary shaft.
摘要翻译： 本发明实现了为发电应用提供的通用发动机的重量和尺寸的减小。 可选的外部装置可以附接到旋转轴的一个轴部分，并且由发电转子（内部转子）和定子构成的轴向间隙型电动机/发电机一体地附接到旋转轴的另一个轴部。
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