- 专利标题: Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein
-
申请号: US13566524申请日: 2012-08-03
-
公开(公告)号: US20130058962A1公开(公告)日: 2013-03-07
- 发明人: Charles B. Shoemaker , Hanping Feng
- 申请人: Charles B. Shoemaker , Hanping Feng
- 申请人地址: US MA Boston
- 专利权人: TUFTS UNIVERSITY
- 当前专利权人: TUFTS UNIVERSITY
- 当前专利权人地址: US MA Boston
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K19/00 ; C07K16/08 ; C07K16/18 ; C07K16/14 ; A61P33/00 ; A61K39/40 ; A61K39/42 ; A61P31/10 ; A61P31/12 ; A61P31/04 ; A61P35/00 ; C07K16/00 ; C07K16/12
摘要:
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant heteromultimeric neutralizing binding protein including two or multiple binding regions, such that the binding regions are not identical, and each binding region specifically binds a non-overlapping portion of the disease agent, thereby treating the subject for exposure to the disease agent. In a related embodiment, the heteromultimeric neutralizing binding protein includes two or multiple binding regions that neutralize a plurality of disease agents. In certain embodiments, the disease agent includes a bacterium, a bacterial protein, a virus, a viral protein, a cancer cell, and a protein or molecule produced therefrom. In certain embodiments, the disease agent is a plurality of different disease agents.