发明申请
![3-AMINO-5-PHENYL-56-DIHYDRO-2H-[1,4]OXAZINES](/docs/US/2013-08-01/US20130196984A1/abs.jpg.600x600.jpg)
- 专利标题： 3-AMINO-5-PHENYL-56-DIHYDRO-2H-[1,4]OXAZINES
- 专利标题（中）： 3-氨基-5-苯基 - 56-二氢-2H- [1,4]氧化物
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申请号： US13798405申请日： 2013-03-13
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公开(公告)号： US20130196984A1公开(公告)日： 2013-08-01
- 发明人: Matteo Andreini , David Banner , Emanuele Gabellieri , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Eoin Power , Mark Rogers-Evans , Massimiliano Travagli , Michela Valacchi , Thomas Woltering , Wolfgang Wostl
- 申请人： Hoffmann-La Roche Inc. , Siena Biotech S.p.A.
- 申请人地址： IT Siena US NJ Nutley
- 专利权人： Siena Biotech S.p.A.,Hoffmann-La Roche Inc.
- 当前专利权人： Siena Biotech S.p.A.,Hoffmann-La Roche Inc.
- 当前专利权人地址： IT Siena US NJ Nutley
- 优先权： EP09168132.0 20090819
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; C07D413/14 ; C07D471/04 ; C07D265/30 ; C07D417/12
![3-AMINO-5-PHENYL-56-DIHYDRO-2H-[1,4]OXAZINES](/abs-image/US/2013/08/01/US20130196984A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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