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![3-AMINO-5-PHENYL-56-DIHYDRO-2H-[1,4]OXAZINES](/abs-image/US/2013/08/01/US20130196984A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130196984A1
公开(公告)日：2013-08-01
申请号：US13798405
申请日：2013-03-13
发明人： Matteo Andreini , David Banner , Emanuele Gabellieri , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Eoin Power , Mark Rogers-Evans , Massimiliano Travagli , Michela Valacchi , Thomas Woltering , Wolfgang Wostl
IPC分类号： C07D413/12 , C07D413/14 , C07D471/04 , C07D265/30 , C07D417/12
CPC分类号： C07D413/12 , C07D265/30 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明涉及具有BACE1和/或BACE2抑制活性的式I的3-氨基-5-苯基-5,6-二氢-2H- [1,4]恶嗪，其制备方法，含有它们的药物组合物及其作为 治疗活性物质。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：US11339120B2
公开(公告)日：2022-05-24
申请号：US16930013
申请日：2020-07-15
发明人： Olivier Gavelle , Uwe Grether , Matthias Nettekoven , Stephan Roever , Mark Rogers-Evans , Didier Rombach
IPC分类号： C07D207/16 , C07D231/12 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D205/04 , C07C235/52 , C07D331/04 , C07D271/06 , C07D213/61 , C07D209/54 , C07D305/06 , C07D207/14 , C07D277/30 , C07C235/48 , C07C237/22 , C07C231/02 , C07D207/10 , C07D277/28 , C07D305/08
摘要： The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：US20220064178A1
公开(公告)日：2022-03-03
申请号：US17400292
申请日：2021-08-12
发明人： Beat Frei , Luca Gobbi , Uwe Grether , Fabienne Ricklin , Stephan Roever , Mark Rogers-Evans , Didier Rombach
IPC分类号： C07D491/107 , A61K9/20 , A61K9/28 , A61K9/48 , A61K47/12 , A61K47/34 , C07D213/81 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/14
摘要： The invention relates to compound of formula (I) wherein R1 to R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：US20210171441A1
公开(公告)日：2021-06-10
申请号：US16930013
申请日：2020-07-15
发明人： Olivier Gavelle , Uwe Grether , Matthias Nettekoven , Stephan Roever , Mark Rogers-Evans , Didier Rombach
IPC分类号： C07C235/52 , C07D209/54 , C07D231/12 , C07D205/04 , C07D401/10 , C07D277/28 , C07D413/12 , C07C231/02 , C07D213/61 , C07D207/14 , C07D207/16 , C07D207/10 , C07C235/48 , C07D305/06 , C07D331/04 , C07D403/10 , C07D413/06 , C07D413/10 , C07D305/08 , C07C237/22 , C07D271/06 , C07D277/30
摘要： The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：US20170334930A1
公开(公告)日：2017-11-23
申请号：US15522877
申请日：2015-10-30
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Ulrike Obst Sander , Jens-Uwe Peters , Mark Rogers-Evans , Didier Rombach , Thomas Woltering
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： The present invention provides a compound of formula (I), having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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![NOVEL TRIAZOLO[4,5-D]PYRIMIDINES](/abs-image/US/2017/07/20/US20170204103A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170204103A1
公开(公告)日：2017-07-20
申请号：US15478435
申请日：2017-04-04
发明人： Uwe Grether , Matthias Nettekoven , Mark Rogers-Evans , Sebastien Schmitt , Benjamin James Stenton
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be for treating.
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公开(公告)号：US20160376262A1
公开(公告)日：2016-12-29
申请号：US15260826
申请日：2016-09-09
IPC分类号： C07D413/12 , C07D401/04 , C07D417/06 , C07D413/14
CPC分类号： C07D413/12 , C07D401/04 , C07D401/12 , C07D413/14 , C07D417/06
摘要： The invention relates to a compound of formula (I) wherein A and R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中A和R 1至R 4如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：US09522886B2
公开(公告)日：2016-12-20
申请号：US14648431
申请日：2013-12-02
发明人： Beat Frei , Luca Gobbi , Uwe Grether , Atsushi Kimbara , Matthias Nettekoven , Stephan Roever , Mark Rogers-Evans , Tanja Schulz-Gasch
IPC分类号： C07D213/81 , C07D401/14 , C07D401/04 , C07D405/14 , C07D405/12 , C07D401/12 , C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14
CPC分类号： C07D213/81 , A61P3/10 , A61P9/00 , A61P27/02 , A61P29/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：US09403808B2
公开(公告)日：2016-08-02
申请号：US13658874
申请日：2012-10-24
发明人： Caterina Bissantz , Baledi Dhurwasulu , Uwe Grether , Anindya Hazra , Paul Hebeisen , Stephan Roever , Mark Rogers-Evans
IPC分类号： C07D241/12 , C07D241/18 , C07D403/04 , C07D413/12 , C07D413/14 , C07D401/12 , C07D405/12 , C07D409/14 , C07D417/14
CPC分类号： C07D413/12 , C07D241/12 , C07D241/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament. In particular, the compound may be used as a preferential agonist of Cannabinoid Receptor 2.
摘要翻译： 本发明涉及式（I）化合物，其中R 1至R 4如说明书和权利要求中所定义。 式（I）化合物可以用作药物。 特别地，该化合物可以用作大麻素受体2的优选激动剂。
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![NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES](/abs-image/US/2016/06/16/US20160168158A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160168158A1
公开(公告)日：2016-06-16
申请号：US15050753
申请日：2016-02-23
发明人： Uwe Grether , Matthias Nettekoven , Mark Rogers-Evans , Stephan Roever , Sebastien Schmitt , Atsushi Kimbara
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中R 1至R 4如说明书和权利要求中所定义。 式（I）化合物可以用作药物。
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