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![3-AMINO-5-PHENYL-56-DIHYDRO-2H-[1,4]OXAZINES](/abs-image/US/2013/08/01/US20130196984A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130196984A1
公开(公告)日：2013-08-01
申请号：US13798405
申请日：2013-03-13
发明人： Matteo Andreini , David Banner , Emanuele Gabellieri , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Eoin Power , Mark Rogers-Evans , Massimiliano Travagli , Michela Valacchi , Thomas Woltering , Wolfgang Wostl
IPC分类号： C07D413/12 , C07D413/14 , C07D471/04 , C07D265/30 , C07D417/12
CPC分类号： C07D413/12 , C07D265/30 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明涉及具有BACE1和/或BACE2抑制活性的式I的3-氨基-5-苯基-5,6-二氢-2H- [1,4]恶嗪，其制备方法，含有它们的药物组合物及其作为 治疗活性物质。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：US20150376180A1
公开(公告)日：2015-12-31
申请号：US14850052
申请日：2015-09-10
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Hans P. Maerki , Alexander V. Mayweg , Xuefei Tan
IPC分类号： C07D417/14 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R9, R10 and R11 are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 9，R 10和R 11如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US20170226085A1
公开(公告)日：2017-08-10
申请号：US15498960
申请日：2017-04-27
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan , Lisha Wang , Dongbo Li , Jun Wu
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, m and n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09636339B2
公开(公告)日：2017-05-02
申请号：US15098738
申请日：2016-04-14
发明人： Johannes Aebi , Kurt Amrein , Robert Britton , Benoit Hornsperger , Bernd Kuhn , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan
IPC分类号： A61K31/472 , C07D217/02 , C07D217/18 , C07D401/06 , C07D401/12 , C07D413/12
CPC分类号： A61K31/472 , C07D217/02 , C07D217/12 , C07D217/18 , C07D401/06 , C07D401/12 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09636338B2
公开(公告)日：2017-05-02
申请号：US15098737
申请日：2016-04-14
发明人： Johannes Aebi , Kurt Amrein , Robert Britton , Benoit Hornsperger , Bernd Kuhn , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan
IPC分类号： A61K31/472 , C07D217/02 , C07D221/04 , C07D401/12 , C07D413/12
CPC分类号： A61K31/472 , C07D217/02 , C07D221/04 , C07D401/12 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09464058B2
公开(公告)日：2016-10-11
申请号：US13766010
申请日：2013-02-13
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Hans P. Maerki , Alexander V. Mayweg , Peter Mohr , Xuefei Tan
IPC分类号： C07D233/64 , C07D409/06 , C07D401/06
CPC分类号： C07D233/64 , C07D401/06 , C07D409/06
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and R4 n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09458135B2
公开(公告)日：2016-10-04
申请号：US14850729
申请日：2015-09-10
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Hans P. Maerki , Alexander V. Mayweg , Xuefei Tan
IPC分类号： C07D215/00 , C07D401/14 , C07D401/10 , C07D401/04 , C07D413/14
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D413/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, R11 and A are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20140336208A1
公开(公告)日：2014-11-13
申请号：US14326861
申请日：2014-07-09
发明人： David Banner , Emanuele Gabellieri , Wolfgang Guba , Hans Hilpert , Benoit Hornsperger , Roland Humm , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Emmanuel Pinard , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
IPC分类号： C07D417/12 , C07D239/70 , C07D405/12 , C07D401/12 , C07D413/12 , C07D409/12 , C07D239/22 , C07D403/12
CPC分类号： C07D417/12 , A61K31/513 , C07D239/22 , C07D239/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： This invention relates to compounds of the formula wherein R1 to R9 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as diabetes, particularly type 2 diabetes, and other metabolic disorders.
摘要翻译： 本发明涉及下式化合物或其药学上可接受的盐：其中R 1至R 9如下所述。 这些化合物是BACE2抑制剂，可用作治疗和/或预防性治疗诸如糖尿病，特别是2型糖尿病和其它代谢疾病的药物。
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公开(公告)号：US20170226079A1
公开(公告)日：2017-08-10
申请号：US15498957
申请日：2017-04-27
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan
IPC分类号： C07D401/04 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R15, R16, R17 and n are as described herein, compositions including the compounds and methods of using the compounds.
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10.发明申请NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS 有权新型苯二酚二氢吡啶衍生物作为醛固酮合成酶抑制剂公开(公告)号：US20160229807A1
公开(公告)日：2016-08-11
申请号：US15098738
申请日：2016-04-14
发明人： Johannes Aebi , Kurt Amrein , Robert Britton , Benoit Hornsperger , Bernd Kuhn , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan
IPC分类号： C07D221/04 , C07D217/18 , C07D401/06 , C07D413/12 , C07D401/12
CPC分类号： A61K31/472 , C07D217/02 , C07D217/12 , C07D217/18 , C07D401/06 , C07D401/12 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，A1和n如本文所述，包括化合物和 使用化合物的方法。
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