发明申请
US20130210009A1 CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE
有权
一个硫代固体相与一个含有硫代核苷酸的寡核苷酸之间的结合
- 专利标题： CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE
- 专利标题（中）： 一个硫代固体相与一个含有硫代核苷酸的寡核苷酸之间的结合
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申请号： US13866412申请日： 2013-04-19
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公开(公告)号： US20130210009A1公开(公告)日： 2013-08-15
- 发明人: Simone Budow , Ping Ding , Dieter Heindl , Alfons Nichtl , Frank Seela
- 申请人： Simone Budow , Ping Ding , Dieter Heindl , Alfons Nichtl , Frank Seela
- 申请人地址： US IN Indianapolis
- 专利权人： ROCHE DIAGNOSTICS OPERATIONS, INC.
- 当前专利权人： ROCHE DIAGNOSTICS OPERATIONS, INC.
- 当前专利权人地址： US IN Indianapolis
- 优先权： EP10188515.0 20101022
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12M1/34 ; C07H21/02
摘要：
An oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic and the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, wherein X is CH or N, R1 is H or NH2, --- indicates a covalent bond, and said oligonucleotide is bound to said solid phase via the sulfur atom of said thiooxonucleotide. Also disclosed are methods for producing such conjugate as well as various uses for such oligonucleotide metal conjugate.
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