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    General purpose structure of an analytical element and its application for analyte determination
    3.
    发明授权
    General purpose structure of an analytical element and its application for analyte determination 有权
    分析元素的通用结构及其分析物测定的应用

    公开(公告)号：US06703196B1

    公开(公告)日：2004-03-09

    申请号：US09215979

    申请日：1998-12-18

    申请人： Jürgen Klepp ,  Gerhard Hiller ,  Alfons Nichtl ,  Ulrike Fischer ,  Martina Hösch

    发明人： Jürgen Klepp ,  Gerhard Hiller ,  Alfons Nichtl ,  Ulrike Fischer ,  Martina Hösch

    IPC分类号： C12Q100

    CPC分类号： G01N33/558 ,  G01N2333/11 ,  G01N2333/16 ,  Y10S435/805 ,  Y10S435/81

    摘要： The invention concerns an analytical element for the determination of an analyte containing in or on material which enables liquid transport between zones, a sample application zone and a detection zone located downstream thereof, wherein the detection zone contains a partner 1 of a specific binding pair 1 immobilized in such a manner that it is able to bind to partner 2 of the specific binding pair 1 which is not the analyte when it contacts it, wherein a labelled partner 1 of a specific binding pair 2 is present upstream of the detection zone impregnated on a material such that it can be detached by liquid and is able to bind to partner 2 of the specific binding pair 2 which is not the analyte when this contacts it as well as a method for the determination of an analyte using this analytical element.

    摘要翻译： 本发明涉及一种分析元件，用于确定含有物质中或物质上的分析物，其使得能够在区域之间进行液体输送，样品施用区域和位于其下游的检测区域，其中检测区域包含特异性结合对1的配偶体1 以这样的方式固定，使得其能够结合特异性结合对1的配偶体2，其不与分析物接触时，其中特异性结合对2的标记配偶体1存在于浸渍在 材料，使得其可以被液体分离，并且能够与特异性结合对2的配偶体2结合，所述特异性结合对2在与其接触时不是分析物，以及使用该分析元件测定分析物的方法。

    CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE
    4.
    发明申请
    CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE 有权
    一个硫代固体相与一个含有硫代核苷酸的寡核苷酸之间的结合

    公开(公告)号：US20130210009A1

    公开(公告)日：2013-08-15

    申请号：US13866412

    申请日：2013-04-19

    申请人： Simone Budow ,  Ping Ding ,  Dieter Heindl ,  Alfons Nichtl ,  Frank Seela

    发明人： Simone Budow ,  Ping Ding ,  Dieter Heindl ,  Alfons Nichtl ,  Frank Seela

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C07H21/02

    CPC分类号： C12Q1/6876 ,  C07H21/02

    摘要： An oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic and the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, wherein X is CH or N, R1 is H or NH2, --- indicates a covalent bond, and said oligonucleotide is bound to said solid phase via the sulfur atom of said thiooxonucleotide. Also disclosed are methods for producing such conjugate as well as various uses for such oligonucleotide metal conjugate.

    摘要翻译： 一种寡核苷酸 - 固相缀合物，其中所述固相是亲核的，并且所述寡核苷酸包含至少一种根据式I的硫氧基核碱基，其中X为CH或N，R 1为H或NH 2，表示共价键，所述寡核苷酸 通过所述硫代核苷酸的硫原子与所述固相结合。 还公开了用于生产这种缀合物的方法以及这种寡核苷酸金属缀合物的各种用途。

    Fluorescent polypeptide complex
    8.
    发明授权
    Fluorescent polypeptide complex 有权
    荧光多肽复合物

    公开(公告)号：US07662920B2

    公开(公告)日：2010-02-16

    申请号：US11538940

    申请日：2006-10-05

    申请人： Albert Geiger ,  Hans Hornauer ,  Alfons Nichtl ,  Peter Sluka

    发明人： Albert Geiger ,  Hans Hornauer ,  Alfons Nichtl ,  Peter Sluka

    IPC分类号： C07K14/00 ,  A61K38/00

    CPC分类号： G01N33/533 ,  C07K14/43595 ,  G01N33/582 ,  Y10S977/705

    摘要： The present invention relates to a method of producing a fluorescent polypeptide complex characterized in that an isolated fluorescent polypeptide is inter-molecularly cross-linked with itself or one or more other polypeptides and wherein said complex is of 40 nm to 500 nm in size, it also relates to a complex obtainable by such method, to conjugates comprising such a fluorescent polypeptide complex and to the use of such complex or conjugate.

    摘要翻译： 本发明涉及一种生产荧光多肽复合物的方法，其特征在于分离的荧光多肽与其自身或一种或多种其他多肽分子内交联，其中所述复合物的大小为40nm至500nm， 还涉及通过这种方法获得的复合物，包含这种荧光多肽复合物的缀合物和这种复合物或缀合物的用途。

    Analyte determination using a general purpose structure of an analytical element
    9.
    发明授权
    Analyte determination using a general purpose structure of an analytical element 有权
    使用分析元素的通用结构进行分析物测定

    公开(公告)号：US07118875B2

    公开(公告)日：2006-10-10

    申请号：US10748560

    申请日：2003-12-30

    申请人： Jürgen Klepp ,  Gerhard Hiller ,  Alfons Nichtl ,  Thomas Fischer ,  Martina Hösch

    发明人： Jürgen Klepp ,  Gerhard Hiller ,  Alfons Nichtl ,  Thomas Fischer ,  Martina Hösch

    IPC分类号： G01N33/53 ,  G01N33/566

    CPC分类号： G01N33/558 ,  G01N2333/11 ,  G01N2333/16 ,  Y10S435/805 ,  Y10S435/81

    摘要： The invention concerns an analytical element for the determination of an analyte containing in or on material which enables liquid transport between zones, a sample application zone and a detection zone located downstream thereof, wherein the detection zone contains a partner 1 of a specific binding pair 1 immobilized in such a manner that it is able to bind to partner 2 of the specific binding pair 1 which is not the analyte when it contacts it, wherein a labelled partner 1 of a specific binding pair 2 is present upstream of the detection zone impregnated on a material such that it can be detached by liquid and is able to bind to partner 2 of the specific binding pair 2 which is not the analyte when this contacts it as well as a method for the determination of an analyte using this analytical element.

    摘要翻译： 本发明涉及一种分析元件，用于确定含有物质的分析物，所述分析物能够在区域之间进行液体输送，样品施用区域和位于其下游的检测区域，其中检测区域包含特异性结合对1的配偶体1 以这样的方式固定，使得其能够与特异性结合对1的配偶体2结合，所述特异性结合对1在与其接触时不是分析物，其中特异性结合对2的标记配偶体1存在浸渍在检测区上游 这种材料使得其可以被液体分离，并且能够与特异性结合对2的配偶体2结合，所述特异性结合对2在与其接触时不是分析物，以及使用该分析元件测定分析物的方法。

    Gold conjugates containing detergent
    10.
    发明授权
    Gold conjugates containing detergent 有权
    含有洗涤剂的金共轭物

    公开(公告)号：US06833275B1

    公开(公告)日：2004-12-21

    申请号：US09633295

    申请日：2000-08-07

    申请人： Alfons Nichtl

    发明人： Alfons Nichtl

    IPC分类号： G01N33544

    CPC分类号： G01N33/553 ,  G01N33/585

    摘要： A composition which contains stabilized conjugates composed of colloidal particles and biomolecules is obtained by adding a detergent to a solution containing biomolecules before or/and during treatment of colloidal particles with this solution.

    摘要翻译： 含有由胶体颗粒和生物分子组成的稳定的共轭物的组合物是通过在用该溶液处理胶体颗粒之前或/和之前通过向含有生物分子的溶液中加入洗涤剂而获得的。