![IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES](/docs/US/2014-01-30/US20140030776A1/abs.jpg.600x600.jpg)
- 专利标题： IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES
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申请号： US13838508申请日： 2013-03-15
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公开(公告)号： US20140030776A1公开(公告)日： 2014-01-30
- 发明人: Dennis FLINT , Steven Cary Rothman , Wonchul Suh , Jean-Francois Tomb , Rick W. Ye
- 申请人： Butamax(TM) Advanced Biofuels LLC
- 申请人地址： US DE Wilmington
- 专利权人： Butamax(TM) Advanced Biofuels LLC
- 当前专利权人： Butamax(TM) Advanced Biofuels LLC
- 当前专利权人地址： US DE Wilmington
- 主分类号： G06F19/22
- IPC分类号： G06F19/22 ; C12P7/16 ; C12P7/40 ; C12N9/88
![IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES](/abs-image/US/2014/01/30/US20140030776A1/abs.jpg.150x150.jpg)
摘要：
A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing DHAD activity for conversion of 2,3-dihydroxyisovalerate to α-ketoisovalerate or 2,3-dihydroxymethylvalerate to α-ketomethylvalerate. Isobutanol and other compounds may be synthesized in pathways that include bacterial [2Fe-2S] DHAD activity.
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