Invention Application
- Patent Title: Novel Anti-IL13 Antibodies and Uses Thereof
- Patent Title (中): 新型抗IL13抗体及其用途
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Application No.: US13971394Application Date: 2013-08-20
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Publication No.: US20140105897A1Publication Date: 2014-04-17
- Inventor: Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
- Applicant: Genentech, Inc.
- Applicant Address: US CA San Fransisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA San Fransisco
- Main IPC: C07K16/24
- IPC: C07K16/24

Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Public/Granted literature
- US09605065B2 Anti-IL13 antibodies and uses thereof Public/Granted day:2017-03-28
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