发明申请
- 专利标题： STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR a-CHAIN AND OF THE INSULIN-LIKE GROWTH FACTOR RECEPTOR a-CHAIN
- 专利标题（中）： 胰岛素受体a链和胰岛素样生长因子受体a链的C端区的结构
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申请号： US14087102申请日： 2013-11-22
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公开(公告)号： US20140154817A1公开(公告)日： 2014-06-05
- 发明人: Michael C. Lawrence , Brian J. Smith , John G.T. Menting , Colin W. Ward
- 申请人： Michael C. Lawrence , Brian J. Smith , John G.T. Menting , Colin W. Ward
- 主分类号： G06F19/12
- IPC分类号： G06F19/12 ; G01N33/566
摘要：
The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.