公开(公告)号：US20140154817A1

公开(公告)日：2014-06-05

申请号：US14087102

申请日：2013-11-22

Applicant: Michael C. Lawrence ,  Brian J. Smith ,  John G.T. Menting ,  Colin W. Ward

Inventor： Michael C. Lawrence ,  Brian J. Smith ,  John G.T. Menting ,  Colin W. Ward

IPC: G06F19/12 ,  G01N33/566

CPC classification number: G16B5/00 ,  C07K14/72 ,  G01N33/566

Abstract: The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.

Abstract translation: 本发明一般涉及胰岛素受体（IR）和胰岛素样生长因子1受体（IGF-1R）的胰岛素结合位点的结构研究。 更具体地，本发明涉及包含IRα链的C末端区域以及IGF-1R的相应区域的IR胞外域的低亲和力胰岛素结合位点的晶体结构，以及 使用晶体和相关的结构信息来筛选和设计与IR和/或IGF-1R的功能相互作用或调节其功能的化合物。

公开(公告)号：US4775001A

公开(公告)日：1988-10-04

申请号：US858758

申请日：1986-05-02

Applicant: Colin W. Ward ,  Norman Stoliar ,  Lewis Marton ,  Geoffrey N. Beeche ,  Leslie Phipps

Inventor： Colin W. Ward ,  Norman Stoliar ,  Lewis Marton ,  Geoffrey N. Beeche ,  Leslie Phipps

IPC: F24F3/00 ,  F24F7/10 ,  F24F3/06 ,  F24F13/04 ,  F24F13/18

CPC classification number: F24F3/00 ,  F24F7/10 ,  F24F2221/38 ,  F24F2221/40

Abstract: A zoned air conditioning system using a room air terminal which has the same horizontal dimensions as a floor tile of a raised tile floor such that the terminal may replace one tile in such a floor. The terminal includes a cool air inlet below the floor for drawing in cooling air circulated in the under floor space and a return air inlet in the top surface of the terminal. The cool air and return air is mixed in a mixing chamber and drawn from the mixing chamber by a fan and returned to the room through an outlet vent. The ratio of cool air to return air mixed in the mixing chamber is controlled by a modulating damper which is controlled in response to the temperature of the return air in order to control the room temperature in the region of the terminal in accordance with an adjustable set point. A heater is also provided in the terminal for those occasions where the return air is cooler than the set point.

Abstract translation: 一种分区式空调系统，其使用与升高的瓷砖地板的地板砖具有相同的水平尺寸的房间空气终端，使得该终端可以代替这种地板中的一个瓦片。 该终端包括位于地板下面的冷空气入口，用于吸入在底板空间中循环的冷却空气和终端顶表面中的回流空气入口。 冷空气和回流空气在混合室中混合并通过风扇从混合室中抽出并通过出口排出口返回到房间。 混合在混合室中的冷空气与返回空气的比例由调节阻尼器控制，该调节阻尼器根据回流空气的温度来控制，以便根据可调组合来控制终端区域中的室温 点。 在返回空气比设定点更冷的场合，终端也设有一个加热器。