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    STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR a-CHAIN AND OF THE INSULIN-LIKE GROWTH FACTOR RECEPTOR a-CHAIN
    1.
    发明申请
    STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR a-CHAIN AND OF THE INSULIN-LIKE GROWTH FACTOR RECEPTOR a-CHAIN 审中-公开
    胰岛素受体a链和胰岛素样生长因子受体a链的C端区的结构

    公开(公告)号：US20140154817A1

    公开(公告)日：2014-06-05

    申请号：US14087102

    申请日：2013-11-22

    申请人： Michael C. Lawrence ,  Brian J. Smith ,  John G.T. Menting ,  Colin W. Ward

    发明人： Michael C. Lawrence ,  Brian J. Smith ,  John G.T. Menting ,  Colin W. Ward

    IPC分类号： G06F19/12 ,  G01N33/566

    CPC分类号： G16B5/00 ,  C07K14/72 ,  G01N33/566

    摘要： The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.

    摘要翻译： 本发明一般涉及胰岛素受体（IR）和胰岛素样生长因子1受体（IGF-1R）的胰岛素结合位点的结构研究。 更具体地，本发明涉及包含IRα链的C末端区域以及IGF-1R的相应区域的IR胞外域的低亲和力胰岛素结合位点的晶体结构，以及 使用晶体和相关的结构信息来筛选和设计与IR和/或IGF-1R的功能相互作用或调节其功能的化合物。