Multi-layer fabrics and products incorporating the same are described in which the fabrics are configured to provide asymmetric resistance to liquid flow from one side of the fabric to the other. In garments or other products worn by a user, the effect can be utilized to prevent penetration of liquids (e.g., rain droplets) and contact of liquids from the exterior with the user's skin while allowing for extraction of droplets (e.g., sweat) in contact with an inner layer of the fabric out of contact with the skin and accelerating their evaporation. Medical and industrial applications of the fabric are contemplated as well.