发明申请
- 专利标题: CETP INHIBITORS
- 专利标题(中): CETP抑制剂
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申请号: US14252256申请日: 2014-04-14
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公开(公告)号: US20140221383A1公开(公告)日: 2014-08-07
- 发明人: Amjad Ali , Joann M. Napolitano , Qiaolin Deng , Zhijian Lu , Peter J. Sinclair , Gayle E. Hallet , Christopher F. Thompson , Nazia Quraishi , Cameron J. Smith , Julianne A. Hunt , Adrian A. Dowst , Yi-Heng Chen , Hong Li
- 申请人: Merck Sharp & Dohme Corp.
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 主分类号: C07D417/04
- IPC分类号: C07D417/04 ; A61K31/497 ; A61K31/506 ; A61K31/4439 ; A61K31/433 ; A61K31/427 ; A61K31/421 ; A61K31/4166 ; A61K31/4168 ; A61K31/4015 ; C07D413/04 ; C07D285/10 ; C07D417/10 ; C07D263/26 ; C07D233/38 ; C07D233/50 ; C07D207/27 ; C07D413/10 ; A61K31/422 ; A61K45/06 ; A61K31/501
摘要:
Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula I, B or R2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a —CH2—.