发明申请
US20140378504A1 METHOD OF USING SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
审中-公开
使用取代的2-AZA-BICYCLO的方法[2.2.2] 3-羟基-3-羧酸（苄基 - 氰基 - 甲基） - 胺类C的抑制剂
![METHOD OF USING SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C](/docs/US/2014-12-25/US20140378504A1/abs.jpg.600x600.jpg)
- 专利标题： METHOD OF USING SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
- 专利标题（中）： 使用取代的2-AZA-BICYCLO的方法[2.2.2] 3-羟基-3-羧酸（苄基 - 氰基 - 甲基） - 胺类C的抑制剂
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申请号： US14483217申请日： 2014-09-11
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公开(公告)号： US20140378504A1公开(公告)日： 2014-12-25
- 发明人: Ralf ANDERSKEWITZ , Matthias GRAUERT , Marc GRUNDL , Thorsten OOST , Alexander PAUTSCH , Stefan PETERS
- 申请人： Ralf ANDERSKEWITZ , Matthias GRAUERT , Marc GRUNDL , Thorsten OOST , Alexander PAUTSCH , Stefan PETERS
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： EP13159242.0 20130314; EP13170006.4 20130531
- 主分类号： C07D221/22
- IPC分类号： C07D221/22
![METHOD OF USING SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C](/abs-image/US/2014/12/25/US20140378504A1/abs.jpg.150x150.jpg)
摘要：
This invention relates to 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
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