发明申请
- 专利标题： GLP-1 ANALOGUE, ITS PREPARATION METHODS AND USE THEREOF
- 专利标题（中）： GLP-1类似物，其制备方法及其用途
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申请号： US14405060申请日： 2012-02-08
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公开(公告)号： US20150274799A1公开(公告)日： 2015-10-01
- 发明人: Min Gong , Gang Fu , Weiren Xu , Lida Tang , Xiaowen Ren , Peng Liu , Yuli Wang , Jiang Wu , Meixiang Zou
- 申请人： Min Gong , Gang Fu , Weiren Xu , Lida Tang , Xiaowen Ren , Peng Liu , Yuli Wang , Jiang Wu , Meixiang Zou
- 申请人地址： CN Tianjin
- 专利权人： TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH
- 当前专利权人： TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH
- 当前专利权人地址： CN Tianjin
- 优先权： CN201110042039.6 20110221
- 国际申请： PCT/CN2012/070958 WO 20120208
- 主分类号： C07K14/605
- IPC分类号： C07K14/605
摘要：
Provided is a GLP-1 analogue having the structure as shown in the general formula A: 7HAEX10TFTSX15VSSYLEX22QAAKEFIX30WLX33KGRG37n1X1Cn2X2 (general formula A), wherein X10 is glycine or cysteine, X15 is aspartic acid or cysteine, X22 is glycine or cysteine, X30 is alanine or cysteine, X33 is valine or cysteine, and at least one of X10, X15, X22, X30 and X33 is cysteine, X1 and X2 respectively is glycine, alanine or valine, n1=1-30, n2=1-30. The general formula A contains two cysteines to form disulfide bonds. Also provided are the preparation methods and the use of said GLP-1 analogue. Said GLP-1 analogue has a prolonged blood half-life compared with GLP-1, and can be used for the treatment of diabetes and obesity.
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