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公开(公告)号:US20150274799A1
公开(公告)日:2015-10-01
申请号:US14405060
申请日:2012-02-08
申请人: Min Gong , Gang Fu , Weiren Xu , Lida Tang , Xiaowen Ren , Peng Liu , Yuli Wang , Jiang Wu , Meixiang Zou
发明人: Min Gong , Gang Fu , Weiren Xu , Lida Tang , Xiaowen Ren , Peng Liu , Yuli Wang , Jiang Wu , Meixiang Zou
IPC分类号: C07K14/605
CPC分类号: C07K14/605 , A61K38/00
摘要: Provided is a GLP-1 analogue having the structure as shown in the general formula A: 7HAEX10TFTSX15VSSYLEX22QAAKEFIX30WLX33KGRG37n1X1Cn2X2 (general formula A), wherein X10 is glycine or cysteine, X15 is aspartic acid or cysteine, X22 is glycine or cysteine, X30 is alanine or cysteine, X33 is valine or cysteine, and at least one of X10, X15, X22, X30 and X33 is cysteine, X1 and X2 respectively is glycine, alanine or valine, n1=1-30, n2=1-30. The general formula A contains two cysteines to form disulfide bonds. Also provided are the preparation methods and the use of said GLP-1 analogue. Said GLP-1 analogue has a prolonged blood half-life compared with GLP-1, and can be used for the treatment of diabetes and obesity.
摘要翻译: 本发明提供具有通式A所示结构的GLP-1类似物:7HAEX10TFTSX15VSSYLEX22QAAKEFIX30WLX33KGRG37n1X1Cn2X2(通式A),其中X10为甘氨酸或半胱氨酸,X15为天冬氨酸或半胱氨酸,X22为甘氨酸或半胱氨酸,X30为丙氨酸或半胱氨酸 X33是缬氨酸或半胱氨酸,X10,X15,X22,X30和X33中的至少一个是半胱氨酸,X1和X2分别是甘氨酸,丙氨酸或缬氨酸,n1 = 1-30,n2 = 1-30。 通式A包含形成二硫键的两个半胱氨酸。 还提供了所述GLP-1类似物的制备方法和用途。 所述GLP-1类似物与GLP-1相比具有延长的血液半衰期,并且可用于治疗糖尿病和肥胖症。
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公开(公告)号:US07790759B2
公开(公告)日:2010-09-07
申请号:US12090169
申请日:2006-10-16
申请人: Jianwu Wang , Weiren Xu , Jianping Wong , Lida Tang , Shijun Zhang , Lijun Liu , Yuli Wang , Xiaowen Ren
发明人: Jianwu Wang , Weiren Xu , Jianping Wong , Lida Tang , Shijun Zhang , Lijun Liu , Yuli Wang , Xiaowen Ren
IPC分类号: A61K31/42 , C07D261/06
CPC分类号: C07D261/08 , A61K31/415 , C07D413/04
摘要: The present invention relates to the field of a medicine for treating diseases associated with inflammation, immunity or infection, and in particular, to glycyrrhetinic acid-30-amide derivatives of general formula I and their preparation, and a pharmaceutical composition containing the same. Said derivatives and composition exhibit anti-inflammatory, analgesic, anti-allergic, cough-preventing, liver-protecting and anti-viral properties, wherein each group is as defined in the description.
摘要翻译: 本发明涉及用于治疗与炎症,免疫或感染有关的疾病的药物领域,特别涉及通式I的甘草次酸 - 酰胺衍生物及其制备方法及含有该药物的药物组合物。 所述衍生物和组合物表现出抗炎,镇痛,抗过敏,咳嗽预防,肝保护和抗病毒性质,其中每组如说明书中所定义。
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公开(公告)号:US20080214636A1
公开(公告)日:2008-09-04
申请号:US12090169
申请日:2006-10-16
申请人: Jianwu Wang , Weiren Xu , Jianping Yong , Lida Tang , Shijun Zhang , Lijun Liu , Yuli Wang , Xiaowen Ren
发明人: Jianwu Wang , Weiren Xu , Jianping Yong , Lida Tang , Shijun Zhang , Lijun Liu , Yuli Wang , Xiaowen Ren
IPC分类号: A61K31/42 , C07D261/08
CPC分类号: C07D261/08 , A61K31/415 , C07D413/04
摘要: The present invention relates to the field of a medicine for treating diseases associated with inflammation, immunity or infection, and in particular, to glycyrrhetinic acid-30-amide derivatives of general formula I and their preparation, and a pharmaceutical composition containing the same. Said derivatives and composition exhibit anti-inflammatory, analgesic, anti-allergic, cough-preventing, liver-protecting and anti-viral properties, wherein each group is as defined in the description.
摘要翻译: 本发明涉及用于治疗与炎症,免疫或感染有关的疾病的药物领域,特别涉及通式I的甘草次酸 - 酰胺衍生物及其制备方法及含有该药物的药物组合物。 所述衍生物和组合物表现出抗炎,镇痛,抗过敏,咳嗽预防,肝保护和抗病毒性质,其中每组如说明书中所定义。
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