GLP-1 ANALOGUE, ITS PREPARATION METHODS AND USE THEREOF
    1.
    发明申请
    GLP-1 ANALOGUE, ITS PREPARATION METHODS AND USE THEREOF 审中-公开
    GLP-1类似物,其制备方法及其用途

    公开(公告)号:US20150274799A1

    公开(公告)日:2015-10-01

    申请号:US14405060

    申请日:2012-02-08

    IPC分类号: C07K14/605

    CPC分类号: C07K14/605 A61K38/00

    摘要: Provided is a GLP-1 analogue having the structure as shown in the general formula A: 7HAEX10TFTSX15VSSYLEX22QAAKEFIX30WLX33KGRG37n1X1Cn2X2   (general formula A), wherein X10 is glycine or cysteine, X15 is aspartic acid or cysteine, X22 is glycine or cysteine, X30 is alanine or cysteine, X33 is valine or cysteine, and at least one of X10, X15, X22, X30 and X33 is cysteine, X1 and X2 respectively is glycine, alanine or valine, n1=1-30, n2=1-30. The general formula A contains two cysteines to form disulfide bonds. Also provided are the preparation methods and the use of said GLP-1 analogue. Said GLP-1 analogue has a prolonged blood half-life compared with GLP-1, and can be used for the treatment of diabetes and obesity.

    摘要翻译: 本发明提供具有通式A所示结构的GLP-1类似物:7HAEX10TFTSX15VSSYLEX22QAAKEFIX30WLX33KGRG37n1X1Cn2X2(通式A),其中X10为甘氨酸或半胱氨酸,X15为天冬氨酸或半胱氨酸,X22为甘氨酸或半胱氨酸,X30为丙氨酸或半胱氨酸 X33是缬氨酸或半胱氨酸,X10,X15,X22,X30和X33中的至少一个是半胱氨酸,X1和X2分别是甘氨酸,丙氨酸或缬氨酸,n1 = 1-30,n2 = 1-30。 通式A包含形成二硫键的两个半胱氨酸。 还提供了所述GLP-1类似物的制备方法和用途。 所述GLP-1类似物与GLP-1相比具有延长的血液半衰期,并且可用于治疗糖尿病和肥胖症。

    Field emission device and field emission display having same
    7.
    发明授权
    Field emission device and field emission display having same 有权
    场发射器件和场发射显示器具有相同的

    公开(公告)号:US09000662B2

    公开(公告)日:2015-04-07

    申请号:US13630255

    申请日:2012-09-28

    摘要: A field emission device includes a cathode and a carbon nanotube (CNT) gate electrode. The CNT gate electrode which is electrically insulated from the cathode includes a CNT layer and a dielectric layer. The CNT layer which has a surface includes a number of micropores. The dielectric layer is coated on the surface of the CNT layer and an inner wall of each of the micropores.

    摘要翻译: 场致发射器件包括阴极和碳纳米管(CNT)栅电极。 与阴极电绝缘的CNT栅极包括CNT层和电介质层。 具有表面的CNT层包括多个微孔。 介电层被涂覆在CNT层的表面和每个微孔的内壁上。

    Automatically arranging of icons on a user interface
    8.
    发明授权
    Automatically arranging of icons on a user interface 有权
    在用户界面上自动排列图标

    公开(公告)号:US08930839B2

    公开(公告)日:2015-01-06

    申请号:US13301792

    申请日:2011-11-22

    申请人: Li He Peng Liu

    发明人: Li He Peng Liu

    IPC分类号: G06F3/048 G06F3/0481

    CPC分类号: G06F3/04817

    摘要: Automatically arranging icons on a user interface is provided. A plurality of icons associated with items are received and displayed on the user interface. An importance score for each icon of the plurality of icons and a similarity score between two or more of the plurality of icons are determined. Further, a user interface coordinate is assigned to at least a portion of the plurality of icons based on the importance and similarity scores. The user interface is then displayed with the at least a portion of the plurality of icons according to the user interface coordinate.

    摘要翻译: 提供在用户界面上自动排列图标。 与项目相关联的多个图标被接收并显示在用户界面上。 确定多个图标的每个图标的重要性得分以及多个图标中的两个或更多个图标之间的相似性得分。 此外,基于重要性和相似性得分,向多个图标的至少一部分分配用户界面坐标。 然后根据用户界面坐标与多个图标的至少一部分显示用户界面。

    Heater
    9.
    发明授权
    Heater 有权
    加热器

    公开(公告)号:US08841588B2

    公开(公告)日:2014-09-23

    申请号:US12589828

    申请日:2009-10-29

    IPC分类号: H05B3/06 H05B3/14

    摘要: A heater includes a substrate, a plurality of first electrode down-leads, a plurality of second electrode down-leads and a plurality of heating units. The plurality of first electrode down-leads are located on the substrate in parallel to each other and the plurality of second electrode down-leads are located on the substrate in parallel to each other. The first electrode down-leads cross the second electrode down-leads and define a plurality of grids. One heating unit is located in each grid. Each heating unit includes a first electrode, a second electrode and a heating element. The heating element includes a carbon nanotube structure.

    摘要翻译: 加热器包括基板,多个第一电极下引线,多个第二电极下引线和多个加热单元。 多个第一电极下引线彼此平行地位于基板上,并且多个第二电极下引线彼此平行地位于基板上。 第一电极下引线穿过第二电极下引线并限定多个栅极。 一个加热单元位于每个网格中。 每个加热单元包括第一电极,第二电极和加热元件。 加热元件包括碳纳米管结构。